INPP5B protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

INPP5B

Inositol polyphosphate-5-phosphatase B. (991 aa)

Predicted Functional Partners:

SACM1L

0.969

OCRL

0.967

CLTC

0.927

PIK3C2B

0.927

INPP4A

0.927

LOC102442976

0.923

APPL1

0.914

G1NVZ4_MYOLU

0.903

PIK3R1

0.898

SYNJ2

0.896

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	CLTC	ENSMLUP00000000775	ENSMLUP00000003326	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.818
APPL1	G1NVZ4_MYOLU	ENSMLUP00000000775	ENSMLUP00000001469	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.768
APPL1	INPP5B	ENSMLUP00000000775	ENSMLUP00000000896	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Inositol polyphosphate-5-phosphatase B.	0.914
APPL1	LOC102442976	ENSMLUP00000000775	ENSMLUP00000013503	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.425
APPL1	OCRL	ENSMLUP00000000775	ENSMLUP00000014585	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	OCRL inositol polyphosphate-5-phosphatase.	0.779
APPL1	PIK3R1	ENSMLUP00000000775	ENSMLUP00000014043	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.740
APPL1	SACM1L	ENSMLUP00000000775	ENSMLUP00000014241	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	SAC1 like phosphatidylinositide phosphatase.	0.445
CLTC	APPL1	ENSMLUP00000003326	ENSMLUP00000000775	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.818
CLTC	G1NVZ4_MYOLU	ENSMLUP00000003326	ENSMLUP00000001469	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.625
CLTC	INPP5B	ENSMLUP00000003326	ENSMLUP00000000896	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Inositol polyphosphate-5-phosphatase B.	0.927
CLTC	LOC102442976	ENSMLUP00000003326	ENSMLUP00000013503	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.999
CLTC	OCRL	ENSMLUP00000003326	ENSMLUP00000014585	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	OCRL inositol polyphosphate-5-phosphatase.	0.898
CLTC	PIK3C2B	ENSMLUP00000003326	ENSMLUP00000006397	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.707
CLTC	PIK3R1	ENSMLUP00000003326	ENSMLUP00000014043	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Phosphoinositide-3-kinase regulatory subunit 1.	0.625
CLTC	SACM1L	ENSMLUP00000003326	ENSMLUP00000014241	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	SAC1 like phosphatidylinositide phosphatase.	0.716
CLTC	SYNJ2	ENSMLUP00000003326	ENSMLUP00000000298	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Synaptojanin 2.	0.791
G1NVZ4_MYOLU	APPL1	ENSMLUP00000001469	ENSMLUP00000000775	Uncharacterized protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.768
G1NVZ4_MYOLU	CLTC	ENSMLUP00000001469	ENSMLUP00000003326	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.625
G1NVZ4_MYOLU	INPP4A	ENSMLUP00000001469	ENSMLUP00000011971	Uncharacterized protein.	Inositol polyphosphate-4-phosphatase type I A.	0.882
G1NVZ4_MYOLU	INPP5B	ENSMLUP00000001469	ENSMLUP00000000896	Uncharacterized protein.	Inositol polyphosphate-5-phosphatase B.	0.903

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

2.57e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 102

1.49

2.84

8.60e-12

GO:0009987

Cellular process

11 of 1718

0.31

0.25

0.0204

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 52

1.74

3.82

2.54e-12

GO:0019843

rRNA binding

4 of 42

1.48

1.21

0.0015

GO:0003723

RNA binding

5 of 107

1.17

0.95

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

9 of 57

1.7

3.75

9.05e-13

GO:0015935

Small ribosomal subunit

2 of 8

1.9

1.15

0.0055

GO:0005622

Intracellular anatomical structure

11 of 1098

0.5

0.44

5.17e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

3 of 8

2.07

1.68

0.00051

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:133

Structural constituent of ribosome

9 of 58

1.69

3.67

1.85e-12

CL:122

Ribosome, and Translation regulator activity

10 of 81

1.59

3.35

7.71e-13

CL:171

Mixed, incl. Translation regulation, and Nucleotide-binding alpha-beta plait domain superfamily

4 of 6

2.32

3.15

6.41e-07

CL:134

rRNA-binding, and EFG, domain V

6 of 31

1.79

3.01

2.57e-08

CL:136

rRNA-binding

5 of 25

1.8

2.59

7.95e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

9 of 57

1.7

3.74

1.00e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 45

1.8

4.24

3.02e-13

GOCC:0022626

Cytosolic ribosome

2 of 12

1.72

0.84

0.0221

GOCC:0044391

Ribosomal subunit

2 of 17

1.57

0.71

0.0366

GOCC:0005622

Intracellular

11 of 1069

0.51

0.44

8.89e-05

GOCC:0110165

Cellular anatomical entity

11 of 1701

0.31

0.26

0.0123

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 54

1.72

3.83

1.05e-12

KW-0699

rRNA-binding

4 of 39

1.51

1.43

0.00036

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