UCN protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

UCN

Urocortin. (128 aa)

Predicted Functional Partners:

CRHR1

0.999

CRHR2

0.999

CRH

0.993

UCN3

0.978

CRHBP

0.887

G1PGT2_MYOLU

0.811

GNG2

0.783

G1QCB9_MYOLU

0.783

GHRL

0.772

SCTR

0.771

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRH	CRHBP	ENSMLUP00000016080	ENSMLUP00000020485	Corticotropin releasing hormone.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.981
CRH	CRHR1	ENSMLUP00000016080	ENSMLUP00000010251	Corticotropin releasing hormone.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.999
CRH	CRHR2	ENSMLUP00000016080	ENSMLUP00000016200	Corticotropin releasing hormone.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.999
CRH	G1PGT2_MYOLU	ENSMLUP00000016080	ENSMLUP00000009860	Corticotropin releasing hormone.	Uncharacterized protein.	0.434
CRH	G1QCB9_MYOLU	ENSMLUP00000016080	ENSMLUP00000021352	Corticotropin releasing hormone.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.799
CRH	GHRL	ENSMLUP00000016080	ENSMLUP00000010938	Corticotropin releasing hormone.	Ghrelin and obestatin prepropeptide.	0.786
CRH	GNG2	ENSMLUP00000016080	ENSMLUP00000001955	Corticotropin releasing hormone.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.799
CRH	SCTR	ENSMLUP00000016080	ENSMLUP00000003678	Corticotropin releasing hormone.	Secretin receptor; Belongs to the G-protein coupled receptor 2 family.	0.731
CRH	UCN	ENSMLUP00000016080	ENSMLUP00000001218	Corticotropin releasing hormone.	Urocortin.	0.993
CRH	UCN3	ENSMLUP00000016080	ENSMLUP00000020078	Corticotropin releasing hormone.	Urocortin 3.	0.974
CRHBP	CRH	ENSMLUP00000020485	ENSMLUP00000016080	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Corticotropin releasing hormone.	0.981
CRHBP	CRHR1	ENSMLUP00000020485	ENSMLUP00000010251	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.605
CRHBP	CRHR2	ENSMLUP00000020485	ENSMLUP00000016200	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.573
CRHBP	UCN	ENSMLUP00000020485	ENSMLUP00000001218	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urocortin.	0.887
CRHBP	UCN3	ENSMLUP00000020485	ENSMLUP00000020078	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urocortin 3.	0.550
CRHR1	CRH	ENSMLUP00000010251	ENSMLUP00000016080	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin releasing hormone.	0.999
CRHR1	CRHBP	ENSMLUP00000010251	ENSMLUP00000020485	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.605
CRHR1	CRHR2	ENSMLUP00000010251	ENSMLUP00000016200	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.900
CRHR1	G1QCB9_MYOLU	ENSMLUP00000010251	ENSMLUP00000021352	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.711
CRHR1	GHRL	ENSMLUP00000010251	ENSMLUP00000010938	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Ghrelin and obestatin prepropeptide.	0.575