CHFR protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CHFR

Checkpoint with forkhead and ring finger domains. (659 aa)

Predicted Functional Partners:

OS9

0.904

ERLEC1

0.904

PARP1

0.883

KATNAL2

0.854

DERL3

0.852

DERL1

0.852

DERL2

0.852

G1NSC4_MYOLU

0.842

VCP

0.842

SPATA5L1

0.842

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHFR	DERL1	ENSMLUP00000001499	ENSMLUP00000008277	Checkpoint with forkhead and ring finger domains.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.852
CHFR	DERL2	ENSMLUP00000001499	ENSMLUP00000013143	Checkpoint with forkhead and ring finger domains.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.852
CHFR	DERL3	ENSMLUP00000001499	ENSMLUP00000004547	Checkpoint with forkhead and ring finger domains.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.852
CHFR	ERLEC1	ENSMLUP00000001499	ENSMLUP00000015428	Checkpoint with forkhead and ring finger domains.	Endoplasmic reticulum lectin 1.	0.904
CHFR	G1NSC4_MYOLU	ENSMLUP00000001499	ENSMLUP00000000022	Checkpoint with forkhead and ring finger domains.	Uncharacterized protein.	0.842
CHFR	KATNAL2	ENSMLUP00000001499	ENSMLUP00000003717	Checkpoint with forkhead and ring finger domains.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.854
CHFR	OS9	ENSMLUP00000001499	ENSMLUP00000005397	Checkpoint with forkhead and ring finger domains.	OS9 endoplasmic reticulum lectin.	0.904
CHFR	PARP1	ENSMLUP00000001499	ENSMLUP00000011191	Checkpoint with forkhead and ring finger domains.	Poly [ADP-ribose] polymerase.	0.883
CHFR	SPATA5L1	ENSMLUP00000001499	ENSMLUP00000018973	Checkpoint with forkhead and ring finger domains.	Spermatogenesis associated 5 like 1.	0.842
CHFR	VCP	ENSMLUP00000001499	ENSMLUP00000005614	Checkpoint with forkhead and ring finger domains.	Valosin containing protein; Belongs to the AAA ATPase family.	0.842
DERL1	CHFR	ENSMLUP00000008277	ENSMLUP00000001499	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Checkpoint with forkhead and ring finger domains.	0.852
DERL1	DERL2	ENSMLUP00000008277	ENSMLUP00000013143	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.982
DERL1	DERL3	ENSMLUP00000008277	ENSMLUP00000004547	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.982
DERL1	ERLEC1	ENSMLUP00000008277	ENSMLUP00000015428	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.988
DERL1	G1NSC4_MYOLU	ENSMLUP00000008277	ENSMLUP00000000022	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.967
DERL1	KATNAL2	ENSMLUP00000008277	ENSMLUP00000003717	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.889
DERL1	OS9	ENSMLUP00000008277	ENSMLUP00000005397	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.991
DERL1	SPATA5L1	ENSMLUP00000008277	ENSMLUP00000018973	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Spermatogenesis associated 5 like 1.	0.967
DERL1	VCP	ENSMLUP00000008277	ENSMLUP00000005614	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.996
DERL2	CHFR	ENSMLUP00000013143	ENSMLUP00000001499	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Checkpoint with forkhead and ring finger domains.	0.852