NGLY1 protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NGLY1

N-glycanase 1. (614 aa)

Predicted Functional Partners:

RAD23B

0.998

KATNAL2

0.990

RAD23A

0.986

AMFR

0.978

PSMC1

0.978

UBXN1

0.967

DERL1

0.967

VCP

0.960

G1NSC4_MYOLU

0.882

SPATA5L1

0.882

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	DERL1	ENSMLUP00000004521	ENSMLUP00000008277	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.999
AMFR	G1NSC4_MYOLU	ENSMLUP00000004521	ENSMLUP00000000022	Autocrine motility factor receptor.	Uncharacterized protein.	0.918
AMFR	KATNAL2	ENSMLUP00000004521	ENSMLUP00000003717	Autocrine motility factor receptor.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.854
AMFR	NGLY1	ENSMLUP00000004521	ENSMLUP00000001563	Autocrine motility factor receptor.	N-glycanase 1.	0.978
AMFR	PSMC1	ENSMLUP00000004521	ENSMLUP00000006816	Autocrine motility factor receptor.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.958
AMFR	RAD23A	ENSMLUP00000004521	ENSMLUP00000011631	Autocrine motility factor receptor.	RAD23 homolog A, nucleotide excision repair protein.	0.793
AMFR	RAD23B	ENSMLUP00000004521	ENSMLUP00000016072	Autocrine motility factor receptor.	RAD23 homolog B, nucleotide excision repair protein.	0.974
AMFR	SPATA5L1	ENSMLUP00000004521	ENSMLUP00000018973	Autocrine motility factor receptor.	Spermatogenesis associated 5 like 1.	0.918
AMFR	UBXN1	ENSMLUP00000004521	ENSMLUP00000000371	Autocrine motility factor receptor.	UBX domain protein 1.	0.976
AMFR	VCP	ENSMLUP00000004521	ENSMLUP00000005614	Autocrine motility factor receptor.	Valosin containing protein; Belongs to the AAA ATPase family.	0.992
DERL1	AMFR	ENSMLUP00000008277	ENSMLUP00000004521	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Autocrine motility factor receptor.	0.999
DERL1	G1NSC4_MYOLU	ENSMLUP00000008277	ENSMLUP00000000022	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.967
DERL1	KATNAL2	ENSMLUP00000008277	ENSMLUP00000003717	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.889
DERL1	NGLY1	ENSMLUP00000008277	ENSMLUP00000001563	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	N-glycanase 1.	0.967
DERL1	PSMC1	ENSMLUP00000008277	ENSMLUP00000006816	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.	0.954
DERL1	RAD23A	ENSMLUP00000008277	ENSMLUP00000011631	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	RAD23 homolog A, nucleotide excision repair protein.	0.720
DERL1	RAD23B	ENSMLUP00000008277	ENSMLUP00000016072	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	RAD23 homolog B, nucleotide excision repair protein.	0.960
DERL1	SPATA5L1	ENSMLUP00000008277	ENSMLUP00000018973	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Spermatogenesis associated 5 like 1.	0.967
DERL1	UBXN1	ENSMLUP00000008277	ENSMLUP00000000371	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBX domain protein 1.	0.990
DERL1	VCP	ENSMLUP00000008277	ENSMLUP00000005614	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.996