Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
FADS3Fatty acid desaturase 3. (448 aa)    
Predicted Functional Partners:
SC5D
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
  
 
 0.785
FDX2
2Fe-2S ferredoxin-type domain-containing protein.
  
 
 0.710
FDX1
Ferredoxin 1.
  
 
 0.710
MSMO1
Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.
  
 
 0.707
FAXDC2
Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family.
  
 
 0.707
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
  
 
 0.707
NUDCD1
NudC domain containing 1.
    
   0.659
SQLE
Squalene epoxidase.
  
 
 0.593
KMO
Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
  
 
 0.593
COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
  
 
 0.593
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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