Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PIEZO2Piezo-type mechanosensitive ion channel component. (2118 aa)    
Predicted Functional Partners:
MCM4
DNA helicase; Belongs to the MCM family.
   
 0.950
CDC45
Cell division cycle 45.
   
 0.948
CDC6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.948
WDHD1
WD repeat and HMG-box DNA binding protein 1.
   
 
 0.945
MCM9
Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.
   
 0.930
MCM2
DNA helicase; Belongs to the MCM family.
   
 0.930
TIPIN
TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.
   
 
 0.926
TIMELESS
Timeless circadian regulator.
   
 
 0.920
MCM3
DNA helicase; Belongs to the MCM family.
    
  0.914
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 
 0.913
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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