| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EID1 | NSMCE3 | ENSMLUP00000022067 | ENSMLUP00000001766 | EP300 interacting inhibitor of differentiation 1. | NSE3 homolog, SMC5-SMC6 complex component. | 0.843 |
| EID1 | NSMCE4A | ENSMLUP00000022067 | ENSMLUP00000010733 | EP300 interacting inhibitor of differentiation 1. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.573 |
| G1PZ51_MYOLU | NSMCE3 | ENSMLUP00000016733 | ENSMLUP00000001766 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | NSE3 homolog, SMC5-SMC6 complex component. | 0.742 |
| G1PZ51_MYOLU | STN1 | ENSMLUP00000016733 | ENSMLUP00000001853 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.488 |
| G1Q8T5_MYOLU | NSMCE3 | ENSMLUP00000020118 | ENSMLUP00000001766 | Uncharacterized protein. | NSE3 homolog, SMC5-SMC6 complex component. | 0.742 |
| G1Q8T5_MYOLU | STN1 | ENSMLUP00000020118 | ENSMLUP00000001853 | Uncharacterized protein. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.488 |
| NSMCE1 | NSMCE2 | ENSMLUP00000007567 | ENSMLUP00000000576 | NSE1 homolog, SMC5-SMC6 complex component. | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | 0.999 |
| NSMCE1 | NSMCE3 | ENSMLUP00000007567 | ENSMLUP00000001766 | NSE1 homolog, SMC5-SMC6 complex component. | NSE3 homolog, SMC5-SMC6 complex component. | 0.983 |
| NSMCE1 | NSMCE4A | ENSMLUP00000007567 | ENSMLUP00000010733 | NSE1 homolog, SMC5-SMC6 complex component. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.999 |
| NSMCE1 | SMC5 | ENSMLUP00000007567 | ENSMLUP00000007067 | NSE1 homolog, SMC5-SMC6 complex component. | Structural maintenance of chromosomes 5. | 0.999 |
| NSMCE1 | SMC6 | ENSMLUP00000007567 | ENSMLUP00000013433 | NSE1 homolog, SMC5-SMC6 complex component. | Structural maintenance of chromosomes 6. | 0.999 |
| NSMCE1 | STN1 | ENSMLUP00000007567 | ENSMLUP00000001853 | NSE1 homolog, SMC5-SMC6 complex component. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.953 |
| NSMCE2 | NSMCE1 | ENSMLUP00000000576 | ENSMLUP00000007567 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | NSE1 homolog, SMC5-SMC6 complex component. | 0.999 |
| NSMCE2 | NSMCE3 | ENSMLUP00000000576 | ENSMLUP00000001766 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | NSE3 homolog, SMC5-SMC6 complex component. | 0.975 |
| NSMCE2 | NSMCE4A | ENSMLUP00000000576 | ENSMLUP00000010733 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.998 |
| NSMCE2 | SMC5 | ENSMLUP00000000576 | ENSMLUP00000007067 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | Structural maintenance of chromosomes 5. | 0.999 |
| NSMCE2 | SMC6 | ENSMLUP00000000576 | ENSMLUP00000013433 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. | Structural maintenance of chromosomes 6. | 0.999 |
| NSMCE3 | EID1 | ENSMLUP00000001766 | ENSMLUP00000022067 | NSE3 homolog, SMC5-SMC6 complex component. | EP300 interacting inhibitor of differentiation 1. | 0.843 |
| NSMCE3 | G1PZ51_MYOLU | ENSMLUP00000001766 | ENSMLUP00000016733 | NSE3 homolog, SMC5-SMC6 complex component. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.742 |
| NSMCE3 | G1Q8T5_MYOLU | ENSMLUP00000001766 | ENSMLUP00000020118 | NSE3 homolog, SMC5-SMC6 complex component. | Uncharacterized protein. | 0.742 |
