| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC45 | CDT1 | ENSMLUP00000002263 | ENSMLUP00000002914 | Cell division cycle 45. | Chromatin licensing and DNA replication factor 1. | 0.990 |
| CDC45 | MCM2 | ENSMLUP00000002263 | ENSMLUP00000021157 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDC45 | MCM3 | ENSMLUP00000002263 | ENSMLUP00000001614 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.998 |
| CDC45 | MCM4 | ENSMLUP00000002263 | ENSMLUP00000003946 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDC45 | MCM5 | ENSMLUP00000002263 | ENSMLUP00000001808 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDC45 | MCM6 | ENSMLUP00000002263 | ENSMLUP00000012619 | Cell division cycle 45. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDC45 | MCM7 | ENSMLUP00000002263 | ENSMLUP00000012871 | Cell division cycle 45. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
| CDC45 | ORC1 | ENSMLUP00000002263 | ENSMLUP00000000953 | Cell division cycle 45. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.996 |
| CDC45 | ORC2 | ENSMLUP00000002263 | ENSMLUP00000001527 | Cell division cycle 45. | Origin recognition complex subunit 2. | 0.990 |
| CDC45 | ORC3 | ENSMLUP00000002263 | ENSMLUP00000005658 | Cell division cycle 45. | Origin recognition complex subunit 3. | 0.997 |
| CDT1 | CDC45 | ENSMLUP00000002914 | ENSMLUP00000002263 | Chromatin licensing and DNA replication factor 1. | Cell division cycle 45. | 0.990 |
| CDT1 | MCM2 | ENSMLUP00000002914 | ENSMLUP00000021157 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDT1 | MCM3 | ENSMLUP00000002914 | ENSMLUP00000001614 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDT1 | MCM4 | ENSMLUP00000002914 | ENSMLUP00000003946 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDT1 | MCM5 | ENSMLUP00000002914 | ENSMLUP00000001808 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDT1 | MCM6 | ENSMLUP00000002914 | ENSMLUP00000012619 | Chromatin licensing and DNA replication factor 1. | DNA helicase; Belongs to the MCM family. | 0.999 |
| CDT1 | MCM7 | ENSMLUP00000002914 | ENSMLUP00000012871 | Chromatin licensing and DNA replication factor 1. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
| CDT1 | ORC1 | ENSMLUP00000002914 | ENSMLUP00000000953 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
| CDT1 | ORC2 | ENSMLUP00000002914 | ENSMLUP00000001527 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 2. | 0.996 |
| CDT1 | ORC3 | ENSMLUP00000002914 | ENSMLUP00000005658 | Chromatin licensing and DNA replication factor 1. | Origin recognition complex subunit 3. | 0.996 |
