| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTC1 | POLA1 | ENSMLUP00000003315 | ENSMLUP00000004138 | CST telomere replication complex component 1. | DNA polymerase. | 0.985 |
| CTC1 | POLA2 | ENSMLUP00000003315 | ENSMLUP00000003539 | CST telomere replication complex component 1. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.943 |
| CTC1 | PRIM1 | ENSMLUP00000003315 | ENSMLUP00000015294 | CST telomere replication complex component 1. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.907 |
| CTC1 | STN1 | ENSMLUP00000003315 | ENSMLUP00000001853 | CST telomere replication complex component 1. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.999 |
| FANCM | POLA1 | ENSMLUP00000006111 | ENSMLUP00000004138 | FA complementation group M. | DNA polymerase. | 0.943 |
| FANCM | STN1 | ENSMLUP00000006111 | ENSMLUP00000001853 | FA complementation group M. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.990 |
| FANCM | WRN | ENSMLUP00000006111 | ENSMLUP00000005366 | FA complementation group M. | WRN RecQ like helicase. | 0.999 |
| MED14 | MED24 | ENSMLUP00000001078 | ENSMLUP00000003045 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator complex subunit 24. | 0.999 |
| MED14 | MED30 | ENSMLUP00000001078 | ENSMLUP00000002353 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Mediator complex subunit 30. | 0.999 |
| MED14 | STN1 | ENSMLUP00000001078 | ENSMLUP00000001853 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.981 |
| MED24 | MED14 | ENSMLUP00000003045 | ENSMLUP00000001078 | Mediator complex subunit 24. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.999 |
| MED24 | MED30 | ENSMLUP00000003045 | ENSMLUP00000002353 | Mediator complex subunit 24. | Mediator complex subunit 30. | 0.999 |
| MED24 | STN1 | ENSMLUP00000003045 | ENSMLUP00000001853 | Mediator complex subunit 24. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.981 |
| MED30 | MED14 | ENSMLUP00000002353 | ENSMLUP00000001078 | Mediator complex subunit 30. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.999 |
| MED30 | MED24 | ENSMLUP00000002353 | ENSMLUP00000003045 | Mediator complex subunit 30. | Mediator complex subunit 24. | 0.999 |
| MED30 | STN1 | ENSMLUP00000002353 | ENSMLUP00000001853 | Mediator complex subunit 30. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.981 |
| POLA1 | CTC1 | ENSMLUP00000004138 | ENSMLUP00000003315 | DNA polymerase. | CST telomere replication complex component 1. | 0.985 |
| POLA1 | FANCM | ENSMLUP00000004138 | ENSMLUP00000006111 | DNA polymerase. | FA complementation group M. | 0.943 |
| POLA1 | POLA2 | ENSMLUP00000004138 | ENSMLUP00000003539 | DNA polymerase. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.999 |
| POLA1 | PRIM1 | ENSMLUP00000004138 | ENSMLUP00000015294 | DNA polymerase. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.999 |