MDH1 protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MDH1

Malate dehydrogenase. (352 aa)

Predicted Functional Partners:

CS

0.989

MDH2

0.980

GOT1

0.974

ACLY

0.970

FH

0.968

LOC102425029

0.968

GOT2

0.964

ENSMLUP00000021834

0.964

PC

0.959

ME3

0.953

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	CS	ENSMLUP00000010854	ENSMLUP00000006129	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Citrate synthase; Belongs to the citrate synthase family.	0.998
ACLY	ENSMLUP00000021834	ENSMLUP00000010854	ENSMLUP00000021834	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	annotation not available	0.895
ACLY	FH	ENSMLUP00000010854	ENSMLUP00000001823	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.859
ACLY	GOT1	ENSMLUP00000010854	ENSMLUP00000006700	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.906
ACLY	GOT2	ENSMLUP00000010854	ENSMLUP00000003414	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.895
ACLY	LOC102425029	ENSMLUP00000010854	ENSMLUP00000019316	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Lyase_1 domain-containing protein.	0.859
ACLY	MDH1	ENSMLUP00000010854	ENSMLUP00000002136	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.970
ACLY	MDH2	ENSMLUP00000010854	ENSMLUP00000016235	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.965
ACLY	ME3	ENSMLUP00000010854	ENSMLUP00000001793	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malic enzyme.	0.782
ACLY	PC	ENSMLUP00000010854	ENSMLUP00000014973	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.950
CS	ACLY	ENSMLUP00000006129	ENSMLUP00000010854	Citrate synthase; Belongs to the citrate synthase family.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.998
CS	ENSMLUP00000021834	ENSMLUP00000006129	ENSMLUP00000021834	Citrate synthase; Belongs to the citrate synthase family.	annotation not available	0.951
CS	FH	ENSMLUP00000006129	ENSMLUP00000001823	Citrate synthase; Belongs to the citrate synthase family.	Uncharacterized protein.	0.979
CS	GOT1	ENSMLUP00000006129	ENSMLUP00000006700	Citrate synthase; Belongs to the citrate synthase family.	Aspartate aminotransferase.	0.942
CS	GOT2	ENSMLUP00000006129	ENSMLUP00000003414	Citrate synthase; Belongs to the citrate synthase family.	Aspartate aminotransferase.	0.951
CS	LOC102425029	ENSMLUP00000006129	ENSMLUP00000019316	Citrate synthase; Belongs to the citrate synthase family.	Lyase_1 domain-containing protein.	0.979
CS	MDH1	ENSMLUP00000006129	ENSMLUP00000002136	Citrate synthase; Belongs to the citrate synthase family.	Malate dehydrogenase.	0.989
CS	MDH2	ENSMLUP00000006129	ENSMLUP00000016235	Citrate synthase; Belongs to the citrate synthase family.	Malate dehydrogenase.	0.995
CS	ME3	ENSMLUP00000006129	ENSMLUP00000001793	Citrate synthase; Belongs to the citrate synthase family.	Malic enzyme.	0.927
CS	PC	ENSMLUP00000006129	ENSMLUP00000014973	Citrate synthase; Belongs to the citrate synthase family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.971