STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SREBF2Sterol regulatory element binding transcription factor 2. (1113 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
   
 0.999
KPNB1
Karyopherin subunit beta 1.
    
 0.995
MBTPS2
Membrane bound transcription factor peptidase, site 2.
    
 0.977
NPC1
NPC intracellular cholesterol transporter 1.
   
 0.972
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.972
EP300
E1A binding protein p300.
    
 0.884
ELOVL6
Elongation of very long chain fatty acids protein.
     
 0.876
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
     
 0.856
MBTPS1
Membrane bound transcription factor peptidase, site 1.
     
 0.839
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
    
 0.839
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.