close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINE2Serpin family E member 2; Belongs to the serpin family. (407 aa)    
Predicted Functional Partners:
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
   
 0.997
F5
Coagulation factor V; Belongs to the multicopper oxidase family.
    
 0.959
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
  
  
 
0.956
PLAU
Plasminogen activator, urokinase.
  
 0.889
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
  
 0.873
VTN
SMB domain-containing protein.
   
 0.837
FGB
Fibrinogen beta chain.
   
 0.782
PLAUR
Plasminogen activator, urokinase receptor.
   
 0.779
FGA
Fibrinogen alpha chain.
   
 0.756
F8
Coagulation factor VIII; Belongs to the multicopper oxidase family.
    
 0.727
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (22%) [HD]