MDM1 protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MDM1

Mdm1 nuclear protein. (723 aa)

Predicted Functional Partners:

ITSN2

0.949

ITSN1

0.916

G1PFG4_MYOLU

0.864

L7N1Q1_MYOLU

0.864

G1PZQ6_MYOLU

0.845

MET

0.825

MST1R

0.825

TRIO

0.798

KALRN

0.798

MYO9A

0.793

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1PFG4_MYOLU	G1PZQ6_MYOLU	ENSMLUP00000009312	ENSMLUP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.434
G1PFG4_MYOLU	KALRN	ENSMLUP00000009312	ENSMLUP00000002140	Uncharacterized protein.	Kalirin RhoGEF kinase.	0.641
G1PFG4_MYOLU	L7N1Q1_MYOLU	ENSMLUP00000009312	ENSMLUP00000012755	Uncharacterized protein.	Uncharacterized protein.	0.897
G1PFG4_MYOLU	MDM1	ENSMLUP00000009312	ENSMLUP00000002470	Uncharacterized protein.	Mdm1 nuclear protein.	0.864
G1PFG4_MYOLU	MST1R	ENSMLUP00000009312	ENSMLUP00000015309	Uncharacterized protein.	Macrophage stimulating 1 receptor.	0.488
G1PFG4_MYOLU	MYO9A	ENSMLUP00000009312	ENSMLUP00000005611	Uncharacterized protein.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.532
G1PFG4_MYOLU	TRIO	ENSMLUP00000009312	ENSMLUP00000000726	Uncharacterized protein.	Trio Rho guanine nucleotide exchange factor.	0.641
G1PZQ6_MYOLU	G1PFG4_MYOLU	ENSMLUP00000016938	ENSMLUP00000009312	Uncharacterized protein.	Uncharacterized protein.	0.434
G1PZQ6_MYOLU	ITSN2	ENSMLUP00000016938	ENSMLUP00000002296	Uncharacterized protein.	Intersectin 2.	0.906
G1PZQ6_MYOLU	KALRN	ENSMLUP00000016938	ENSMLUP00000002140	Uncharacterized protein.	Kalirin RhoGEF kinase.	0.457
G1PZQ6_MYOLU	L7N1Q1_MYOLU	ENSMLUP00000016938	ENSMLUP00000012755	Uncharacterized protein.	Uncharacterized protein.	0.434
G1PZQ6_MYOLU	MDM1	ENSMLUP00000016938	ENSMLUP00000002470	Uncharacterized protein.	Mdm1 nuclear protein.	0.845
G1PZQ6_MYOLU	MET	ENSMLUP00000016938	ENSMLUP00000007213	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.822
G1PZQ6_MYOLU	MST1R	ENSMLUP00000016938	ENSMLUP00000015309	Uncharacterized protein.	Macrophage stimulating 1 receptor.	0.822
G1PZQ6_MYOLU	MYO9A	ENSMLUP00000016938	ENSMLUP00000005611	Uncharacterized protein.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.499
G1PZQ6_MYOLU	TRIO	ENSMLUP00000016938	ENSMLUP00000000726	Uncharacterized protein.	Trio Rho guanine nucleotide exchange factor.	0.457
ITSN1	ITSN2	ENSMLUP00000016474	ENSMLUP00000002296	Intersectin 1.	Intersectin 2.	0.975
ITSN1	KALRN	ENSMLUP00000016474	ENSMLUP00000002140	Intersectin 1.	Kalirin RhoGEF kinase.	0.415
ITSN1	MDM1	ENSMLUP00000016474	ENSMLUP00000002470	Intersectin 1.	Mdm1 nuclear protein.	0.916
ITSN1	MET	ENSMLUP00000016474	ENSMLUP00000007213	Intersectin 1.	MET proto-oncogene, receptor tyrosine kinase.	0.622

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

12

average node degree:

2.18

avg. local clustering coefficient:

0.913

expected number of edges:

11

PPI enrichment p-value:

0.418

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051963

Regulation of synapse assembly

6 of 120

1.97

3.23

5.38e-08

GO:0098742

Cell-cell adhesion via plasma-membrane adhesion molecules

7 of 197

1.82

3.14

1.70e-08

GO:0099560

Synaptic membrane adhesion

4 of 28

2.43

2.97

1.99e-06

GO:0050808

Synapse organization

8 of 317

1.67

2.91

7.06e-09

GO:0050807

Regulation of synapse organization

7 of 258

1.71

2.76

5.38e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030246

Carbohydrate binding

4 of 276

1.43

0.69

0.0343

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099240

Intrinsic component of synaptic membrane

7 of 210

1.8

3.19

7.08e-09

GO:0099146

Intrinsic component of postsynaptic density membrane

4 of 63

2.08

2.54

6.22e-06

GO:0098936

Intrinsic component of postsynaptic membrane

5 of 150

1.8

2.42

2.45e-06

GO:0098978

Glutamatergic synapse

8 of 481

1.49

2.41

1.26e-08

GO:0099699

Integral component of synaptic membrane

5 of 195

1.68

2.14

6.22e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21589

Mixed, incl. Leucine-rich repeats, typical (most populated) subfamily, and Receptor-type tyrosine-protein phosphatases

8 of 150

2.0

4.55

7.34e-12

CL:21591

Mixed, incl. Leucine-rich repeats, typical (most populated) subfamily, and Netrin-1 signaling

6 of 77

2.16

3.96

3.67e-09

CL:21606

Mixed, incl. Teneurin Intracellular Region, and Latrophilin Cytoplasmic C-terminal region

4 of 11

2.83

3.8

9.06e-08

CL:21811

Regulation of postsynaptic density assembly, and Chondroitin sulfate proteoglycan binding

2 of 5

2.87

1.44

0.0025

CL:21609

Teneurin Intracellular Region, and Galactose binding lectin domain

2 of 5

2.87

1.44

0.0025

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan04514

Cell adhesion molecules

3 of 128

1.64

0.92

0.0132

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8849932

Synaptic adhesion-like molecules

3 of 21

2.43

2.07

0.00013

MAP-373080

Class B/2 (Secretin family receptors)

4 of 68

2.04

2.05

7.58e-05

MAP-388844

Receptor-type tyrosine-protein phosphatases

3 of 27

2.32

1.96

0.00019

MAP-6794362

Protein-protein interactions at synapses

4 of 93

1.91

1.87

0.00013

MAP-112316

Neuronal System

4 of 436

1.24

0.74

0.0171

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098978

Glutamatergic synapse

6 of 165

1.83

2.93

9.25e-08

GOCC:0099240

Intrinsic component of synaptic membrane

6 of 177

1.8

2.87

9.77e-08

GOCC:0099699

Integral component of synaptic membrane

5 of 164

1.76

2.31

3.77e-06

GOCC:0031226

Intrinsic component of plasma membrane

8 of 610

1.39

2.02

9.25e-08

GOCC:0045202

Synapse

9 of 827

1.31

1.9

2.83e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

6 of 1164

0.98

0.72

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02354

Latrophilin Cytoplasmic C-terminal region

3 of 3

3.27

2.92

5.15e-06

PF02140

Galactose binding lectin domain

3 of 4

3.15

2.92

5.15e-06

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

3 of 9

2.8

2.57

1.88e-05

PF00002

7 transmembrane receptor (Secretin family)

3 of 45

2.1

1.53

0.0011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00284

Olfactomedin-like domains

3 of 11

2.71

2.44

3.21e-05

SM00303

G-protein-coupled receptor proteolytic site domain

3 of 28

2.3

1.95

0.00020

SM00008

Domain present in hormone receptors

2 of 18

2.32

1.03

0.0128

SM00194

Protein tyrosine phosphatase, catalytic domain

2 of 35

2.03

0.84

0.0267

SM00408

Immunoglobulin C-2 Type

3 of 173

1.51

0.82

0.0188

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About