Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CRKCRK proto-oncogene, adaptor protein. (304 aa)    
Predicted Functional Partners:
GAB1
GRB2 associated binding protein 1.
    
 0.999
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 0.999
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.999
PTK2
Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.998
CRKL
CRK like proto-oncogene, adaptor protein.
  
 
0.998
ELMO1
Engulfment and cell motility 1.
    
 0.998
CBL
Cbl proto-oncogene.
    
 0.997
G1P5B5_MYOLU
Uncharacterized protein.
    
 0.996
SRC
Tyrosine-protein kinase.
   
 0.996
ABL2
Tyrosine-protein kinase.
    
0.995
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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