TOP1 protein (Myotis lucifugus) - STRING interaction network

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TOP1

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (748 aa)

Predicted Functional Partners:

TOP2B

0.968

TOP2A

0.966

G1PX81_MYOLU

0.948

LOC102433260

0.948

RNASEH2A

0.947

RECQL4

0.895

BLM

0.893

WRN

0.892

PARP1

0.887

POLE

0.875

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	PARP1	ENSMLUP00000013381	ENSMLUP00000011191	BLM RecQ like helicase.	Poly [ADP-ribose] polymerase.	0.495
BLM	POLE	ENSMLUP00000013381	ENSMLUP00000008325	BLM RecQ like helicase.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.871
BLM	RNASEH2A	ENSMLUP00000013381	ENSMLUP00000011578	BLM RecQ like helicase.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.803
BLM	TOP1	ENSMLUP00000013381	ENSMLUP00000002762	BLM RecQ like helicase.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.893
BLM	TOP2A	ENSMLUP00000013381	ENSMLUP00000007215	BLM RecQ like helicase.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.770
BLM	TOP2B	ENSMLUP00000013381	ENSMLUP00000001556	BLM RecQ like helicase.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.748
BLM	WRN	ENSMLUP00000013381	ENSMLUP00000005366	BLM RecQ like helicase.	WRN RecQ like helicase.	0.845
G1PX81_MYOLU	PARP1	ENSMLUP00000016043	ENSMLUP00000011191	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.651
G1PX81_MYOLU	RNASEH2A	ENSMLUP00000016043	ENSMLUP00000011578	Uncharacterized protein.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.565
G1PX81_MYOLU	TOP1	ENSMLUP00000016043	ENSMLUP00000002762	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.948
G1PX81_MYOLU	TOP2A	ENSMLUP00000016043	ENSMLUP00000007215	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.409
G1PX81_MYOLU	TOP2B	ENSMLUP00000016043	ENSMLUP00000001556	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.409
G1PX81_MYOLU	WRN	ENSMLUP00000016043	ENSMLUP00000005366	Uncharacterized protein.	WRN RecQ like helicase.	0.421
LOC102433260	PARP1	ENSMLUP00000018291	ENSMLUP00000011191	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.651
LOC102433260	RNASEH2A	ENSMLUP00000018291	ENSMLUP00000011578	Uncharacterized protein.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.565
LOC102433260	TOP1	ENSMLUP00000018291	ENSMLUP00000002762	Uncharacterized protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]	0.948
LOC102433260	TOP2A	ENSMLUP00000018291	ENSMLUP00000007215	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.409
LOC102433260	TOP2B	ENSMLUP00000018291	ENSMLUP00000001556	Uncharacterized protein.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.409
LOC102433260	WRN	ENSMLUP00000018291	ENSMLUP00000005366	Uncharacterized protein.	WRN RecQ like helicase.	0.421
PARP1	BLM	ENSMLUP00000011191	ENSMLUP00000013381	Poly [ADP-ribose] polymerase.	BLM RecQ like helicase.	0.495

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