G1NZH5_MYOLU protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

G1NZH5_MYOLU

Uncharacterized protein. (52 aa)

Predicted Functional Partners:

HMGCL

0.963

MCCC1

0.947

ENSMLUP00000021666

0.947

HMGCLL1

0.937

SCP2

0.936

MCCC2

0.934

ACAA1

0.927

HADH

0.926

HSDL2

0.918

HMGCS2

0.908

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ENSMLUP00000021666	ENSMLUP00000010671	ENSMLUP00000021666	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	annotation not available	0.764
ACAA1	G1NZH5_MYOLU	ENSMLUP00000010671	ENSMLUP00000002869	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein.	0.927
ACAA1	HADH	ENSMLUP00000010671	ENSMLUP00000008084	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxyacyl-CoA dehydrogenase.	0.995
ACAA1	HMGCL	ENSMLUP00000010671	ENSMLUP00000004813	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.947
ACAA1	HMGCLL1	ENSMLUP00000010671	ENSMLUP00000002461	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.947
ACAA1	HMGCS2	ENSMLUP00000010671	ENSMLUP00000002732	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.992
ACAA1	HSDL2	ENSMLUP00000010671	ENSMLUP00000015952	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxysteroid dehydrogenase like 2.	0.960
ACAA1	MCCC1	ENSMLUP00000010671	ENSMLUP00000011169	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Methylcrotonoyl-CoA carboxylase 1.	0.764
ACAA1	MCCC2	ENSMLUP00000010671	ENSMLUP00000002550	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Methylcrotonoyl-CoA carboxylase 2.	0.860
ACAA1	SCP2	ENSMLUP00000010671	ENSMLUP00000002198	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.972
ENSMLUP00000021666	ACAA1	ENSMLUP00000021666	ENSMLUP00000010671	annotation not available	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.764
ENSMLUP00000021666	G1NZH5_MYOLU	ENSMLUP00000021666	ENSMLUP00000002869	annotation not available	Uncharacterized protein.	0.947
ENSMLUP00000021666	HADH	ENSMLUP00000021666	ENSMLUP00000008084	annotation not available	Hydroxyacyl-CoA dehydrogenase.	0.736
ENSMLUP00000021666	HMGCL	ENSMLUP00000021666	ENSMLUP00000004813	annotation not available	3-hydroxy-3-methylglutaryl-CoA lyase.	0.889
ENSMLUP00000021666	HMGCLL1	ENSMLUP00000021666	ENSMLUP00000002461	annotation not available	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.877
ENSMLUP00000021666	HMGCS2	ENSMLUP00000021666	ENSMLUP00000002732	annotation not available	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.613
ENSMLUP00000021666	HSDL2	ENSMLUP00000021666	ENSMLUP00000015952	annotation not available	Hydroxysteroid dehydrogenase like 2.	0.843
ENSMLUP00000021666	MCCC2	ENSMLUP00000021666	ENSMLUP00000002550	annotation not available	Methylcrotonoyl-CoA carboxylase 2.	0.999
ENSMLUP00000021666	SCP2	ENSMLUP00000021666	ENSMLUP00000002198	annotation not available	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.833
G1NZH5_MYOLU	ACAA1	ENSMLUP00000002869	ENSMLUP00000010671	Uncharacterized protein.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.927

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.728

expected number of edges:

14

PPI enrichment p-value:

3.99e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

4 of 62

2.02

2.15

4.11e-05

GO:0070828

Heterochromatin organization

4 of 68

1.98

2.1

4.74e-05

GO:0050872

White fat cell differentiation

3 of 22

2.34

1.97

0.00019

GO:0045444

Fat cell differentiation

4 of 124

1.72

1.59

0.00034

GO:0006325

Chromatin organization

7 of 523

1.34

1.54

1.89e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001222

Transcription corepressor binding

6 of 58

2.22

4.11

2.51e-09

GO:0042826

Histone deacetylase binding

4 of 130

1.7

1.55

0.00040

GO:0098882

Structural constituent of presynaptic active zone

2 of 6

2.73

1.51

0.0018

GO:0051287

NAD binding

3 of 64

1.88

1.39

0.0016

GO:0008134

Transcription factor binding

7 of 660

1.24

1.35

3.15e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035098

ESC/E(Z) complex

4 of 12

2.73

3.71

1.20e-07

GO:0016581

NuRD complex

4 of 18

2.56

3.42

3.22e-07

GO:0017053

Transcription repressor complex

5 of 82

2.0

2.96

3.76e-07

GO:0005667

Transcription regulator complex

10 of 518

1.5

2.86

8.60e-12

GO:0016589

NURF complex

3 of 8

2.78

2.8

6.96e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7538

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, and Histone methyltransferase activity (H3-K9 specific)

4 of 7

2.97

3.81

1.01e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05220

Chronic myeloid leukemia

6 of 87

2.05

3.82

2.68e-09

map04330

Notch signaling pathway

4 of 69

1.97

2.31

1.45e-05

map05200

Pathways in cancer

6 of 558

1.24

1.33

4.55e-05

map04310

Wnt signaling pathway

3 of 205

1.38

0.78

0.0190

map04218

Cellular senescence

3 of 198

1.39

0.78

0.0190

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 63

2.11

3.02

5.36e-07

MAP-8943724

Regulation of PTEN gene transcription

5 of 71

2.06

2.97

5.36e-07

MAP-6804758

Regulation of TP53 Activity through Acetylation

4 of 40

2.21

2.74

3.58e-06

MAP-3214815

HDACs deacetylate histones

4 of 41

2.2

2.73

3.58e-06

MAP-4641265

Repression of WNT target genes

3 of 13

2.57

2.54

1.84e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001688

Cochlear ganglion

2 of 3

3.03

1.2

0.0069

BTO:0003667

Inner hair cell

2 of 6

2.73

1.19

0.0069

BTO:0004725

Embryonic fibroblast

3 of 142

1.53

0.76

0.0276

BTO:0000379

Embryo

5 of 1013

0.9

0.51

0.0345

BTO:0000174

Embryonic structure

6 of 1491

0.81

0.49

0.0276

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035098

ESC/E(Z) complex

4 of 11

2.77

3.6

2.07e-07

GOCC:0098831

Presynaptic active zone cytoplasmic component

3 of 15

2.51

2.23

6.89e-05

GOCC:0098681

Synaptic ribbon

2 of 3

3.03

1.67

0.00096

GOCC:0098684

Photoreceptor ribbon synapse

2 of 10

2.51

1.27

0.0046

GOCC:0090545

CHD-type complex

2 of 11

2.47

1.26

0.0048

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12265

Histone-binding protein RBBP4 or subunit C of CAF1 complex

3 of 3

3.21

2.83

7.69e-06

PF02826

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

3 of 4

3.08

2.82

7.69e-06

PF08504

Runx inhibition domain

2 of 3

3.03

1.44

0.0025

PF00853

Runt domain

2 of 3

3.03

1.44

0.0025

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