RUNX3 protein (Myotis lucifugus) - STRING interaction network

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RUNX3

Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (376 aa)

Predicted Functional Partners:

CBFB

0.996

SRC

0.973

ZFHX3

0.967

TGFB1

0.965

MDM2

0.962

MYSM1

0.959

TBX21

0.919

ETS1

0.914

SMAD3

0.886

YAP1

0.862

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBFB	ETS1	ENSMLUP00000010013	ENSMLUP00000019940	Core-binding factor subunit beta.	ETS proto-oncogene 1, transcription factor.	0.810
CBFB	RUNX3	ENSMLUP00000010013	ENSMLUP00000003088	Core-binding factor subunit beta.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.996
CBFB	SMAD3	ENSMLUP00000010013	ENSMLUP00000001990	Core-binding factor subunit beta.	Mothers against decapentaplegic homolog.	0.595
CBFB	TGFB1	ENSMLUP00000010013	ENSMLUP00000011916	Core-binding factor subunit beta.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.582
CBFB	YAP1	ENSMLUP00000010013	ENSMLUP00000000777	Core-binding factor subunit beta.	Yes associated protein 1.	0.689
ETS1	CBFB	ENSMLUP00000019940	ENSMLUP00000010013	ETS proto-oncogene 1, transcription factor.	Core-binding factor subunit beta.	0.810
ETS1	RUNX3	ENSMLUP00000019940	ENSMLUP00000003088	ETS proto-oncogene 1, transcription factor.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.914
ETS1	SMAD3	ENSMLUP00000019940	ENSMLUP00000001990	ETS proto-oncogene 1, transcription factor.	Mothers against decapentaplegic homolog.	0.669
ETS1	TBX21	ENSMLUP00000019940	ENSMLUP00000013231	ETS proto-oncogene 1, transcription factor.	T-box transcription factor 21.	0.505
MDM2	RUNX3	ENSMLUP00000009109	ENSMLUP00000003088	MDM2 proto-oncogene.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.962
MDM2	SRC	ENSMLUP00000009109	ENSMLUP00000017214	MDM2 proto-oncogene.	Tyrosine-protein kinase.	0.872
MYSM1	RUNX3	ENSMLUP00000001534	ENSMLUP00000003088	Myb like, SWIRM and MPN domains 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.959
MYSM1	SMAD3	ENSMLUP00000001534	ENSMLUP00000001990	Myb like, SWIRM and MPN domains 1.	Mothers against decapentaplegic homolog.	0.420
MYSM1	YAP1	ENSMLUP00000001534	ENSMLUP00000000777	Myb like, SWIRM and MPN domains 1.	Yes associated protein 1.	0.635
RUNX3	CBFB	ENSMLUP00000003088	ENSMLUP00000010013	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Core-binding factor subunit beta.	0.996
RUNX3	ETS1	ENSMLUP00000003088	ENSMLUP00000019940	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	ETS proto-oncogene 1, transcription factor.	0.914
RUNX3	MDM2	ENSMLUP00000003088	ENSMLUP00000009109	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	MDM2 proto-oncogene.	0.962
RUNX3	MYSM1	ENSMLUP00000003088	ENSMLUP00000001534	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Myb like, SWIRM and MPN domains 1.	0.959
RUNX3	SMAD3	ENSMLUP00000003088	ENSMLUP00000001990	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Mothers against decapentaplegic homolog.	0.886
RUNX3	SRC	ENSMLUP00000003088	ENSMLUP00000017214	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	Tyrosine-protein kinase.	0.973

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