ZIC2 protein (Myotis lucifugus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

ZIC2

Zic family member 2. (465 aa)

Predicted Functional Partners:

MTMR11

0.764

G1PBB6_MYOLU

0.763

G1PUN4_MYOLU

0.761

OTX2

0.668

TFCP2L1

0.650

G1QAC2_MYOLU

0.650

LHX5

0.633

G1PZQ6_MYOLU

0.627

TGIF1

0.597

SUFU

0.588

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1PBB6_MYOLU	G1PUN4_MYOLU	ENSMLUP00000007633	ENSMLUP00000014999	Uncharacterized protein.	Uncharacterized protein.	0.763
G1PBB6_MYOLU	MTMR11	ENSMLUP00000007633	ENSMLUP00000009859	Uncharacterized protein.	Myotubularin related protein 11.	0.410
G1PBB6_MYOLU	ZIC2	ENSMLUP00000007633	ENSMLUP00000003099	Uncharacterized protein.	Zic family member 2.	0.763
G1PUN4_MYOLU	G1PBB6_MYOLU	ENSMLUP00000014999	ENSMLUP00000007633	Uncharacterized protein.	Uncharacterized protein.	0.763
G1PUN4_MYOLU	G1PZQ6_MYOLU	ENSMLUP00000014999	ENSMLUP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.627
G1PUN4_MYOLU	SUFU	ENSMLUP00000014999	ENSMLUP00000011456	Uncharacterized protein.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.989
G1PUN4_MYOLU	ZIC2	ENSMLUP00000014999	ENSMLUP00000003099	Uncharacterized protein.	Zic family member 2.	0.761
G1PZQ6_MYOLU	G1PUN4_MYOLU	ENSMLUP00000016938	ENSMLUP00000014999	Uncharacterized protein.	Uncharacterized protein.	0.627
G1PZQ6_MYOLU	ZIC2	ENSMLUP00000016938	ENSMLUP00000003099	Uncharacterized protein.	Zic family member 2.	0.627
G1QAC2_MYOLU	OTX2	ENSMLUP00000020655	ENSMLUP00000017624	Uncharacterized protein.	Orthodenticle homeobox 2.	0.455
G1QAC2_MYOLU	ZIC2	ENSMLUP00000020655	ENSMLUP00000003099	Uncharacterized protein.	Zic family member 2.	0.650
LHX5	ZIC2	ENSMLUP00000008556	ENSMLUP00000003099	LIM homeobox 5.	Zic family member 2.	0.633
MTMR11	G1PBB6_MYOLU	ENSMLUP00000009859	ENSMLUP00000007633	Myotubularin related protein 11.	Uncharacterized protein.	0.410
MTMR11	ZIC2	ENSMLUP00000009859	ENSMLUP00000003099	Myotubularin related protein 11.	Zic family member 2.	0.764
OTX2	G1QAC2_MYOLU	ENSMLUP00000017624	ENSMLUP00000020655	Orthodenticle homeobox 2.	Uncharacterized protein.	0.455
OTX2	TFCP2L1	ENSMLUP00000017624	ENSMLUP00000002701	Orthodenticle homeobox 2.	Transcription factor CP2 like 1.	0.455
OTX2	ZIC2	ENSMLUP00000017624	ENSMLUP00000003099	Orthodenticle homeobox 2.	Zic family member 2.	0.668
SUFU	G1PUN4_MYOLU	ENSMLUP00000011456	ENSMLUP00000014999	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	Uncharacterized protein.	0.989
SUFU	ZIC2	ENSMLUP00000011456	ENSMLUP00000003099	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	Zic family member 2.	0.588
TFCP2L1	OTX2	ENSMLUP00000002701	ENSMLUP00000017624	Transcription factor CP2 like 1.	Orthodenticle homeobox 2.	0.455