BRIP1 protein (Myotis lucifugus) - STRING interaction network

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Score

BRIP1

BRCA1 interacting protein C-terminal helicase 1. (1176 aa)

Predicted Functional Partners:

TOPBP1

0.997

BRCA1

0.995

MLH1

0.989

WRN

0.984

BARD1

0.984

SLF1

0.976

NBN

0.970

CHEK1

0.968

ERCC3

0.967

GTF2H1

0.967

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSMLUP00000012866	ENSMLUP00000003770	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	BRIP1	ENSMLUP00000012866	ENSMLUP00000003526	BRCA1 associated RING domain 1.	BRCA1 interacting protein C-terminal helicase 1.	0.984
BARD1	CHEK1	ENSMLUP00000012866	ENSMLUP00000005324	BRCA1 associated RING domain 1.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.877
BARD1	MLH1	ENSMLUP00000012866	ENSMLUP00000003246	BRCA1 associated RING domain 1.	MutL homolog 1.	0.758
BARD1	NBN	ENSMLUP00000012866	ENSMLUP00000008036	BRCA1 associated RING domain 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.997
BARD1	SLF1	ENSMLUP00000012866	ENSMLUP00000008401	BRCA1 associated RING domain 1.	SMC5-SMC6 complex localization factor 1.	0.998
BARD1	TOPBP1	ENSMLUP00000012866	ENSMLUP00000004862	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.997
BARD1	WRN	ENSMLUP00000012866	ENSMLUP00000005366	BRCA1 associated RING domain 1.	WRN RecQ like helicase.	0.993
BRCA1	BARD1	ENSMLUP00000003770	ENSMLUP00000012866	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	BRIP1	ENSMLUP00000003770	ENSMLUP00000003526	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 interacting protein C-terminal helicase 1.	0.995
BRCA1	CHEK1	ENSMLUP00000003770	ENSMLUP00000005324	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.956
BRCA1	MLH1	ENSMLUP00000003770	ENSMLUP00000003246	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL homolog 1.	0.941
BRCA1	NBN	ENSMLUP00000003770	ENSMLUP00000008036	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.987
BRCA1	SLF1	ENSMLUP00000003770	ENSMLUP00000008401	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	SMC5-SMC6 complex localization factor 1.	0.958
BRCA1	TOPBP1	ENSMLUP00000003770	ENSMLUP00000004862	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA topoisomerase II binding protein 1.	0.998
BRCA1	WRN	ENSMLUP00000003770	ENSMLUP00000005366	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	WRN RecQ like helicase.	0.960
BRIP1	BARD1	ENSMLUP00000003526	ENSMLUP00000012866	BRCA1 interacting protein C-terminal helicase 1.	BRCA1 associated RING domain 1.	0.984
BRIP1	BRCA1	ENSMLUP00000003526	ENSMLUP00000003770	BRCA1 interacting protein C-terminal helicase 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.995
BRIP1	CHEK1	ENSMLUP00000003526	ENSMLUP00000005324	BRCA1 interacting protein C-terminal helicase 1.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.968
BRIP1	ERCC3	ENSMLUP00000003526	ENSMLUP00000006786	BRCA1 interacting protein C-terminal helicase 1.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.967