RBM4 protein (Myotis lucifugus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

RBM4

RNA binding motif protein 4. (382 aa)

Predicted Functional Partners:

LOC102430660

0.858

SRSF2

0.805

SRSF3

0.800

G1QC37_MYOLU

0.800

G1QGF9_MYOLU

0.800

RBM11

0.793

EIF4E

0.746

G1QA52_MYOLU

0.746

NCBP1

0.733

LDOC1

0.713

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF4E	NCBP1	ENSMLUP00000004593	ENSMLUP00000013854	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Nuclear cap binding protein subunit 1.	0.887
EIF4E	RBM4	ENSMLUP00000004593	ENSMLUP00000003716	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	RNA binding motif protein 4.	0.746
G1QA52_MYOLU	NCBP1	ENSMLUP00000020585	ENSMLUP00000013854	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Nuclear cap binding protein subunit 1.	0.831
G1QA52_MYOLU	RBM4	ENSMLUP00000020585	ENSMLUP00000003716	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	RNA binding motif protein 4.	0.746
G1QC37_MYOLU	NCBP1	ENSMLUP00000021270	ENSMLUP00000013854	RRM domain-containing protein.	Nuclear cap binding protein subunit 1.	0.703
G1QC37_MYOLU	RBM4	ENSMLUP00000021270	ENSMLUP00000003716	RRM domain-containing protein.	RNA binding motif protein 4.	0.800
G1QC37_MYOLU	SRSF2	ENSMLUP00000021270	ENSMLUP00000022051	RRM domain-containing protein.	RRM domain-containing protein.	0.996
G1QGF9_MYOLU	NCBP1	ENSMLUP00000022792	ENSMLUP00000013854	RRM domain-containing protein.	Nuclear cap binding protein subunit 1.	0.703
G1QGF9_MYOLU	RBM4	ENSMLUP00000022792	ENSMLUP00000003716	RRM domain-containing protein.	RNA binding motif protein 4.	0.800
G1QGF9_MYOLU	SRSF2	ENSMLUP00000022792	ENSMLUP00000022051	RRM domain-containing protein.	RRM domain-containing protein.	0.996
LDOC1	RBM4	ENSMLUP00000007147	ENSMLUP00000003716	LDOC1 regulator of NFKB signaling.	RNA binding motif protein 4.	0.713
LOC102430660	NCBP1	ENSMLUP00000000402	ENSMLUP00000013854	Uncharacterized protein.	Nuclear cap binding protein subunit 1.	0.561
LOC102430660	RBM11	ENSMLUP00000000402	ENSMLUP00000005230	Uncharacterized protein.	RNA binding motif protein 11.	0.903
LOC102430660	RBM4	ENSMLUP00000000402	ENSMLUP00000003716	Uncharacterized protein.	RNA binding motif protein 4.	0.858
NCBP1	EIF4E	ENSMLUP00000013854	ENSMLUP00000004593	Nuclear cap binding protein subunit 1.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.887
NCBP1	G1QA52_MYOLU	ENSMLUP00000013854	ENSMLUP00000020585	Nuclear cap binding protein subunit 1.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.831
NCBP1	G1QC37_MYOLU	ENSMLUP00000013854	ENSMLUP00000021270	Nuclear cap binding protein subunit 1.	RRM domain-containing protein.	0.703
NCBP1	G1QGF9_MYOLU	ENSMLUP00000013854	ENSMLUP00000022792	Nuclear cap binding protein subunit 1.	RRM domain-containing protein.	0.703
NCBP1	LOC102430660	ENSMLUP00000013854	ENSMLUP00000000402	Nuclear cap binding protein subunit 1.	Uncharacterized protein.	0.561
NCBP1	RBM4	ENSMLUP00000013854	ENSMLUP00000003716	Nuclear cap binding protein subunit 1.	RNA binding motif protein 4.	0.733

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051045

Negative regulation of membrane protein ectodomain proteolysis

4 of 5

3.57

6.73

4.23e-10

GO:0009725

Response to hormone

4 of 416

1.65

1.82

0.00033

GO:0034097

Response to cytokine

4 of 431

1.63

1.8

0.00035

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008191

Metalloendopeptidase inhibitor activity

4 of 13

3.16

6.05

2.64e-09

GO:0002020

Protease binding

4 of 73

2.41

3.98

7.50e-07

GO:0008270

Zinc ion binding

4 of 778

1.38

1.25

0.0021

GO:0046872

Metal ion binding

5 of 4369

0.73

0.43

0.0489

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

5 of 521

1.65

2.37

7.39e-06

GO:0005576

Extracellular region

5 of 2032

1.06

0.9

0.0022

GO:0005615

Extracellular space

4 of 1283

1.16

0.82

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23867

Hemopexin-like repeats, and P domain

5 of 35

2.82

6.9

5.91e-11

CL:23868

Hemopexin-like repeats, and Protease inhibitor I35 (TIMP)

4 of 29

2.81

5.38

1.42e-08

CL:23874

Peptidoglycan binding-like, and Protease inhibitor I35 (TIMP)

3 of 15

2.97

3.92

2.83e-06

CL:23876

Peptidase M10A, cysteine switch, zinc binding site, and Tissue inhibitor of metalloproteinase, conserved site

2 of 10

2.97

2.04

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1592389

Activation of Matrix Metalloproteinases

3 of 57

2.39

2.42

0.00027

MAP-1474228

Degradation of the extracellular matrix

3 of 198

1.85

1.43

0.0052

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000088

Cardiovascular system

3 of 531

1.42

1.39

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0964

Secreted

4 of 281

1.82

2.42

3.67e-05

KW-1015

Disulfide bond

5 of 1389

1.22

1.31

0.00013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027465

Proteinase inhibitor I35b (TIMP), C-terminal

4 of 4

3.67

6.95

2.16e-10

IPR001820

Protease inhibitor I35 (TIMP)

4 of 4

3.67

6.95

2.16e-10

IPR030490

Tissue inhibitor of metalloproteinase, conserved site

3 of 3

3.67

4.94

1.44e-07

IPR001134

Netrin domain

4 of 33

2.75

4.9

6.79e-08

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

4 of 34

2.74

4.89

6.79e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00206

Tissue inhibitor of metalloproteinase family.

4 of 4

3.67

7.64

2.29e-11

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