DOT1L protein (Myotis lucifugus) - STRING interaction network

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Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DOT1L	G1Q6C8_MYOLU	ENSMLUP00000004017	ENSMLUP00000019261	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Uncharacterized protein.	0.949
DOT1L	MED8	ENSMLUP00000004017	ENSMLUP00000011491	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.900
DOT1L	MLLT1	ENSMLUP00000004017	ENSMLUP00000012946	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	MLLT1 super elongation complex subunit.	0.916
DOT1L	MLLT10	ENSMLUP00000004017	ENSMLUP00000013572	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	MLLT10 histone lysine methyltransferase DOT1L cofactor.	0.980
DOT1L	MLLT3	ENSMLUP00000004017	ENSMLUP00000003593	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	MLLT3 super elongation complex subunit.	0.916
DOT1L	ORC1	ENSMLUP00000004017	ENSMLUP00000000953	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.864
DOT1L	SETD2	ENSMLUP00000004017	ENSMLUP00000009203	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	SET domain containing 2, histone lysine methyltransferase.	0.906
DOT1L	SIRT1	ENSMLUP00000004017	ENSMLUP00000003901	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	Sirtuin 1.	0.920
DOT1L	SIRT5	ENSMLUP00000004017	ENSMLUP00000013308	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.860
DOT1L	TFB2M	ENSMLUP00000004017	ENSMLUP00000003572	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	0.902
G1Q6C8_MYOLU	DOT1L	ENSMLUP00000019261	ENSMLUP00000004017	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.949
G1Q6C8_MYOLU	MLLT1	ENSMLUP00000019261	ENSMLUP00000012946	Uncharacterized protein.	MLLT1 super elongation complex subunit.	0.462
G1Q6C8_MYOLU	MLLT3	ENSMLUP00000019261	ENSMLUP00000003593	Uncharacterized protein.	MLLT3 super elongation complex subunit.	0.462
G1Q6C8_MYOLU	ORC1	ENSMLUP00000019261	ENSMLUP00000000953	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.757
G1Q6C8_MYOLU	SETD2	ENSMLUP00000019261	ENSMLUP00000009203	Uncharacterized protein.	SET domain containing 2, histone lysine methyltransferase.	0.954
G1Q6C8_MYOLU	SIRT1	ENSMLUP00000019261	ENSMLUP00000003901	Uncharacterized protein.	Sirtuin 1.	0.916
G1Q6C8_MYOLU	SIRT5	ENSMLUP00000019261	ENSMLUP00000013308	Uncharacterized protein.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]	0.835
MED8	DOT1L	ENSMLUP00000011491	ENSMLUP00000004017	Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.900
MED8	TFB2M	ENSMLUP00000011491	ENSMLUP00000003572	Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	0.908
MLLT1	DOT1L	ENSMLUP00000012946	ENSMLUP00000004017	MLLT1 super elongation complex subunit.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.916