node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO2 | ISCU | ENSMLUP00000002251 | ENSMLUP00000007250 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.632 |
ACO2 | LIAS | ENSMLUP00000002251 | ENSMLUP00000004184 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.639 |
ACO2 | NFU1 | ENSMLUP00000002251 | ENSMLUP00000008267 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | NFU1 iron-sulfur cluster scaffold. | 0.763 |
G1NYM1_MYOLU | LIAS | ENSMLUP00000002516 | ENSMLUP00000004184 | Nudix hydrolase domain-containing protein. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.677 |
GCSH | KCNE3 | ENSMLUP00000005284 | ENSMLUP00000012194 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Potassium voltage-gated channel subfamily E regulatory subunit 3. | 0.888 |
GCSH | LIAS | ENSMLUP00000005284 | ENSMLUP00000004184 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.984 |
GCSH | LIPT1 | ENSMLUP00000005284 | ENSMLUP00000010523 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Lipoyltransferase 1. | 0.989 |
GCSH | LIPT2 | ENSMLUP00000005284 | ENSMLUP00000017597 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. | 0.990 |
GCSH | NFU1 | ENSMLUP00000005284 | ENSMLUP00000008267 | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | NFU1 iron-sulfur cluster scaffold. | 0.418 |
ISCU | ACO2 | ENSMLUP00000007250 | ENSMLUP00000002251 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 0.632 |
ISCU | LIAS | ENSMLUP00000007250 | ENSMLUP00000004184 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.708 |
ISCU | NFU1 | ENSMLUP00000007250 | ENSMLUP00000008267 | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFU1 iron-sulfur cluster scaffold. | 0.940 |
KCNE3 | GCSH | ENSMLUP00000012194 | ENSMLUP00000005284 | Potassium voltage-gated channel subfamily E regulatory subunit 3. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.888 |
KCNE3 | LIAS | ENSMLUP00000012194 | ENSMLUP00000004184 | Potassium voltage-gated channel subfamily E regulatory subunit 3. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.848 |
KCNE3 | LIPT1 | ENSMLUP00000012194 | ENSMLUP00000010523 | Potassium voltage-gated channel subfamily E regulatory subunit 3. | Lipoyltransferase 1. | 0.911 |
KCNE3 | NFU1 | ENSMLUP00000012194 | ENSMLUP00000008267 | Potassium voltage-gated channel subfamily E regulatory subunit 3. | NFU1 iron-sulfur cluster scaffold. | 0.454 |
LIAS | ACO2 | ENSMLUP00000004184 | ENSMLUP00000002251 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 0.639 |
LIAS | G1NYM1_MYOLU | ENSMLUP00000004184 | ENSMLUP00000002516 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Nudix hydrolase domain-containing protein. | 0.677 |
LIAS | GCSH | ENSMLUP00000004184 | ENSMLUP00000005284 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.984 |
LIAS | ISCU | ENSMLUP00000004184 | ENSMLUP00000007250 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.708 |