NOTCH3 protein (Myotis lucifugus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

NOTCH3

Notch receptor 3. (2210 aa)

Predicted Functional Partners:

RBPJ

0.997

JAG1

0.987

DLL4

0.980

DLL1

0.980

RBPJL

0.965

DVL3

0.961

MAML1

0.959

MAML2

0.958

MAML3

0.958

NUMBL

0.956

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL4	ENSMLUP00000004628	ENSMLUP00000004134	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.886
DLL1	DVL3	ENSMLUP00000004628	ENSMLUP00000012316	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Dishevelled segment polarity protein 3.	0.521
DLL1	JAG1	ENSMLUP00000004628	ENSMLUP00000008601	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.674
DLL1	MAML1	ENSMLUP00000004628	ENSMLUP00000007386	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.830
DLL1	MAML2	ENSMLUP00000004628	ENSMLUP00000007875	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.828
DLL1	MAML3	ENSMLUP00000004628	ENSMLUP00000008069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.827
DLL1	NOTCH3	ENSMLUP00000004628	ENSMLUP00000004411	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.980
DLL1	NUMBL	ENSMLUP00000004628	ENSMLUP00000000362	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NUMB like endocytic adaptor protein.	0.736
DLL1	RBPJ	ENSMLUP00000004628	ENSMLUP00000015672	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.904
DLL1	RBPJL	ENSMLUP00000004628	ENSMLUP00000005391	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.746
DLL4	DLL1	ENSMLUP00000004134	ENSMLUP00000004628	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.886
DLL4	DVL3	ENSMLUP00000004134	ENSMLUP00000012316	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Dishevelled segment polarity protein 3.	0.521
DLL4	JAG1	ENSMLUP00000004134	ENSMLUP00000008601	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.658
DLL4	MAML1	ENSMLUP00000004134	ENSMLUP00000007386	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.806
DLL4	MAML2	ENSMLUP00000004134	ENSMLUP00000007875	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 2.	0.807
DLL4	MAML3	ENSMLUP00000004134	ENSMLUP00000008069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.805
DLL4	NOTCH3	ENSMLUP00000004134	ENSMLUP00000004411	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.980
DLL4	NUMBL	ENSMLUP00000004134	ENSMLUP00000000362	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	NUMB like endocytic adaptor protein.	0.643
DLL4	RBPJ	ENSMLUP00000004134	ENSMLUP00000015672	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.896
DLL4	RBPJL	ENSMLUP00000004134	ENSMLUP00000005391	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.756