STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WWP2E3 ubiquitin-protein ligase. (861 aa)    
Predicted Functional Partners:
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.933
SMAD7
Mothers against decapentaplegic homolog.
    
 0.918
NDFIP1
Nedd4 family interacting protein 1.
    
 
 0.894
NDFIP2
Nedd4 family interacting protein 2.
    
 
 0.894
DTX1
Deltex E3 ubiquitin ligase 1.
    
 0.891
UBB
Uncharacterized protein.
    
 0.885
LOC102442670
Uncharacterized protein.
    
 0.885
ENSMLUP00000021652
annotation not available
    
 0.885
ITCH
E3 ubiquitin-protein ligase.
  
 
0.880
G1Q1H5_MYOLU
Uncharacterized protein.
   
 0.864
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.