| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APIP | PHRF1 | ENSMLUP00000016947 | ENSMLUP00000005215 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | PHD and ring finger domains 1. | 0.754 |
| APIP | SPPL3 | ENSMLUP00000016947 | ENSMLUP00000017652 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | Signal peptide peptidase like 3. | 0.733 |
| APIP | TAOK3 | ENSMLUP00000016947 | ENSMLUP00000002067 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | TAO kinase 3. | 0.698 |
| DNMT1 | PHRF1 | ENSMLUP00000001254 | ENSMLUP00000005215 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | PHD and ring finger domains 1. | 0.730 |
| DNMT1 | SCAF1 | ENSMLUP00000001254 | ENSMLUP00000006925 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | SR-related CTD associated factor 1. | 0.409 |
| GTF3C1 | PHRF1 | ENSMLUP00000004664 | ENSMLUP00000005215 | General transcription factor IIIC subunit 1. | PHD and ring finger domains 1. | 0.720 |
| PHRF1 | APIP | ENSMLUP00000005215 | ENSMLUP00000016947 | PHD and ring finger domains 1. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. | 0.754 |
| PHRF1 | DNMT1 | ENSMLUP00000005215 | ENSMLUP00000001254 | PHD and ring finger domains 1. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.730 |
| PHRF1 | GTF3C1 | ENSMLUP00000005215 | ENSMLUP00000004664 | PHD and ring finger domains 1. | General transcription factor IIIC subunit 1. | 0.720 |
| PHRF1 | PRPF19 | ENSMLUP00000005215 | ENSMLUP00000016049 | PHD and ring finger domains 1. | Pre-mRNA processing factor 19. | 0.689 |
| PHRF1 | SCAF1 | ENSMLUP00000005215 | ENSMLUP00000006925 | PHD and ring finger domains 1. | SR-related CTD associated factor 1. | 0.724 |
| PHRF1 | SMG5 | ENSMLUP00000005215 | ENSMLUP00000007780 | PHD and ring finger domains 1. | SMG5 nonsense mediated mRNA decay factor. | 0.734 |
| PHRF1 | SNRNP35 | ENSMLUP00000005215 | ENSMLUP00000018440 | PHD and ring finger domains 1. | Small nuclear ribonucleoprotein U11/U12 subunit 35. | 0.745 |
| PHRF1 | SPPL3 | ENSMLUP00000005215 | ENSMLUP00000017652 | PHD and ring finger domains 1. | Signal peptide peptidase like 3. | 0.733 |
| PHRF1 | TAOK3 | ENSMLUP00000005215 | ENSMLUP00000002067 | PHD and ring finger domains 1. | TAO kinase 3. | 0.722 |
| PHRF1 | TRNT1 | ENSMLUP00000005215 | ENSMLUP00000010804 | PHD and ring finger domains 1. | tRNA nucleotidyl transferase 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.691 |
| PRPF19 | PHRF1 | ENSMLUP00000016049 | ENSMLUP00000005215 | Pre-mRNA processing factor 19. | PHD and ring finger domains 1. | 0.689 |
| PRPF19 | SCAF1 | ENSMLUP00000016049 | ENSMLUP00000006925 | Pre-mRNA processing factor 19. | SR-related CTD associated factor 1. | 0.431 |
| PRPF19 | SNRNP35 | ENSMLUP00000016049 | ENSMLUP00000018440 | Pre-mRNA processing factor 19. | Small nuclear ribonucleoprotein U11/U12 subunit 35. | 0.862 |
| PRPF19 | TRNT1 | ENSMLUP00000016049 | ENSMLUP00000010804 | Pre-mRNA processing factor 19. | tRNA nucleotidyl transferase 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.666 |