close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH1Notch receptor 1. (1802 aa)    
Predicted Functional Partners:
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.999
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.999
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.999
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.999
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.997
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.996
NCSTN
Nicastrin.
    
 0.993
PSENEN
Presenilin enhancer, gamma-secretase subunit.
    
 0.982
PSEN2
Presenilin 2.
    
 0.980
DTX1
Deltex E3 ubiquitin ligase 1.
    
 0.977
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.