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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)    
Predicted Functional Partners:
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.999
CLSPN
Claspin.
   
 0.998
CHEK2
Checkpoint kinase 2.
   
0.996
G1PZT1_MYOLU
Uncharacterized protein.
   
 0.993
RAD51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 0.993
MCM4
DNA helicase; Belongs to the MCM family.
   
 0.991
CDC25C
Cell division cycle 25C.
   
 0.989
TOPBP1
DNA topoisomerase II binding protein 1.
   
 0.988
CDC45
Cell division cycle 45.
   
 0.986
G1PHU0_MYOLU
Rhodanese domain-containing protein.
   
 0.983
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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