TP53 protein (Myotis lucifugus) - STRING interaction network

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TP53

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)

Predicted Functional Partners:

MDM2

0.995

MDM4

0.994

EP300

0.993

USP7

0.990

SIRT1

0.984

CDKN1A

0.984

HIPK2

0.981

DAXX

0.980

UBE3A

0.976

G1PHV0_MYOLU

0.976

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN1A	EP300	ENSMLUP00000009726	ENSMLUP00000013493	Cyclin dependent kinase inhibitor 1A.	E1A binding protein p300.	0.779
CDKN1A	G1PHV0_MYOLU	ENSMLUP00000009726	ENSMLUP00000010259	Cyclin dependent kinase inhibitor 1A.	FAT domain-containing protein.	0.476
CDKN1A	MDM2	ENSMLUP00000009726	ENSMLUP00000009109	Cyclin dependent kinase inhibitor 1A.	MDM2 proto-oncogene.	0.941
CDKN1A	MDM4	ENSMLUP00000009726	ENSMLUP00000006508	Cyclin dependent kinase inhibitor 1A.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.724
CDKN1A	SIRT1	ENSMLUP00000009726	ENSMLUP00000003901	Cyclin dependent kinase inhibitor 1A.	Sirtuin 1.	0.694
CDKN1A	TP53	ENSMLUP00000009726	ENSMLUP00000005861	Cyclin dependent kinase inhibitor 1A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.984
DAXX	EP300	ENSMLUP00000006916	ENSMLUP00000013493	Death domain associated protein.	E1A binding protein p300.	0.474
DAXX	G1PHV0_MYOLU	ENSMLUP00000006916	ENSMLUP00000010259	Death domain associated protein.	FAT domain-containing protein.	0.466
DAXX	HIPK2	ENSMLUP00000006916	ENSMLUP00000015971	Death domain associated protein.	Homeodomain interacting protein kinase 2.	0.773
DAXX	MDM2	ENSMLUP00000006916	ENSMLUP00000009109	Death domain associated protein.	MDM2 proto-oncogene.	0.978
DAXX	MDM4	ENSMLUP00000006916	ENSMLUP00000006508	Death domain associated protein.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.915
DAXX	TP53	ENSMLUP00000006916	ENSMLUP00000005861	Death domain associated protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.980
DAXX	USP7	ENSMLUP00000006916	ENSMLUP00000004307	Death domain associated protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.995
EP300	CDKN1A	ENSMLUP00000013493	ENSMLUP00000009726	E1A binding protein p300.	Cyclin dependent kinase inhibitor 1A.	0.779
EP300	DAXX	ENSMLUP00000013493	ENSMLUP00000006916	E1A binding protein p300.	Death domain associated protein.	0.474
EP300	G1PHV0_MYOLU	ENSMLUP00000013493	ENSMLUP00000010259	E1A binding protein p300.	FAT domain-containing protein.	0.487
EP300	HIPK2	ENSMLUP00000013493	ENSMLUP00000015971	E1A binding protein p300.	Homeodomain interacting protein kinase 2.	0.803
EP300	MDM2	ENSMLUP00000013493	ENSMLUP00000009109	E1A binding protein p300.	MDM2 proto-oncogene.	0.906
EP300	MDM4	ENSMLUP00000013493	ENSMLUP00000006508	E1A binding protein p300.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.513
EP300	SIRT1	ENSMLUP00000013493	ENSMLUP00000003901	E1A binding protein p300.	Sirtuin 1.	0.787

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