CD40LG protein (Myotis lucifugus) - STRING interaction network

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Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	CD40LG	ENSMLUP00000005488	ENSMLUP00000007096	CD40 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.956
CD40	CD86	ENSMLUP00000005488	ENSMLUP00000013974	CD40 molecule.	CD86 molecule.	0.875
CD40	ICOS	ENSMLUP00000005488	ENSMLUP00000008760	CD40 molecule.	Inducible T cell costimulator.	0.716
CD40	IFNG	ENSMLUP00000005488	ENSMLUP00000002447	CD40 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.688
CD40	IL4	ENSMLUP00000005488	ENSMLUP00000015107	CD40 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.690
CD40	LTA	ENSMLUP00000005488	ENSMLUP00000003608	CD40 molecule.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.789
CD40	TNF	ENSMLUP00000005488	ENSMLUP00000003613	CD40 molecule.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.872
CD40	TNFSF13B	ENSMLUP00000005488	ENSMLUP00000004874	CD40 molecule.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.807
CD40	TRAF1	ENSMLUP00000005488	ENSMLUP00000004594	CD40 molecule.	TNF receptor-associated factor.	0.815
CD40LG	CD40	ENSMLUP00000007096	ENSMLUP00000005488	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD40 molecule.	0.956
CD40LG	CD86	ENSMLUP00000007096	ENSMLUP00000013974	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD86 molecule.	0.853
CD40LG	ICOS	ENSMLUP00000007096	ENSMLUP00000008760	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Inducible T cell costimulator.	0.991
CD40LG	IFNG	ENSMLUP00000007096	ENSMLUP00000002447	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.837
CD40LG	IL4	ENSMLUP00000007096	ENSMLUP00000015107	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.846
CD40LG	LTA	ENSMLUP00000007096	ENSMLUP00000003608	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin alpha; Belongs to the tumor necrosis factor family.	0.858
CD40LG	LTBR	ENSMLUP00000007096	ENSMLUP00000013003	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Lymphotoxin beta receptor.	0.918
CD40LG	TNF	ENSMLUP00000007096	ENSMLUP00000003613	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.856
CD40LG	TNFSF13B	ENSMLUP00000007096	ENSMLUP00000004874	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.887
CD40LG	TRAF1	ENSMLUP00000007096	ENSMLUP00000004594	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNF receptor-associated factor.	0.857
CD86	CD40	ENSMLUP00000013974	ENSMLUP00000005488	CD86 molecule.	CD40 molecule.	0.875