CAPN13 protein (Myotis lucifugus) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

CAPN13

Calpain 13; Belongs to the peptidase C2 family. (668 aa)

Predicted Functional Partners:

CAPNS1

0.930

CAST

0.896

YPEL5

0.769

YIPF6

0.754

LCLAT1

0.739

ARHGAP4

0.735

ZNF106

0.716

PEF1

0.692

GCA

0.692

SRI

0.692

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP4	CAPN13	ENSMLUP00000012976	ENSMLUP00000007307	Rho GTPase activating protein 4.	Calpain 13; Belongs to the peptidase C2 family.	0.735
ARHGAP4	YIPF6	ENSMLUP00000012976	ENSMLUP00000013429	Rho GTPase activating protein 4.	Protein YIPF.	0.735
CAPN13	ARHGAP4	ENSMLUP00000007307	ENSMLUP00000012976	Calpain 13; Belongs to the peptidase C2 family.	Rho GTPase activating protein 4.	0.735
CAPN13	CAPNS1	ENSMLUP00000007307	ENSMLUP00000017097	Calpain 13; Belongs to the peptidase C2 family.	Calpain small subunit 1.	0.930
CAPN13	CAST	ENSMLUP00000007307	ENSMLUP00000014627	Calpain 13; Belongs to the peptidase C2 family.	Calpastatin.	0.896
CAPN13	GCA	ENSMLUP00000007307	ENSMLUP00000008685	Calpain 13; Belongs to the peptidase C2 family.	Grancalcin.	0.692
CAPN13	LCLAT1	ENSMLUP00000007307	ENSMLUP00000007261	Calpain 13; Belongs to the peptidase C2 family.	Lysocardiolipin acyltransferase 1.	0.739
CAPN13	PEF1	ENSMLUP00000007307	ENSMLUP00000008371	Calpain 13; Belongs to the peptidase C2 family.	Penta-EF-hand domain containing 1.	0.692
CAPN13	SRI	ENSMLUP00000007307	ENSMLUP00000012732	Calpain 13; Belongs to the peptidase C2 family.	Sorcin.	0.692
CAPN13	YIPF6	ENSMLUP00000007307	ENSMLUP00000013429	Calpain 13; Belongs to the peptidase C2 family.	Protein YIPF.	0.754
CAPN13	YPEL5	ENSMLUP00000007307	ENSMLUP00000008994	Calpain 13; Belongs to the peptidase C2 family.	Protein yippee-like; Belongs to the yippee family.	0.769
CAPN13	ZNF106	ENSMLUP00000007307	ENSMLUP00000022312	Calpain 13; Belongs to the peptidase C2 family.	Zinc finger protein 106.	0.716
CAPNS1	CAPN13	ENSMLUP00000017097	ENSMLUP00000007307	Calpain small subunit 1.	Calpain 13; Belongs to the peptidase C2 family.	0.930
CAPNS1	CAST	ENSMLUP00000017097	ENSMLUP00000014627	Calpain small subunit 1.	Calpastatin.	0.986
CAST	CAPN13	ENSMLUP00000014627	ENSMLUP00000007307	Calpastatin.	Calpain 13; Belongs to the peptidase C2 family.	0.896
CAST	CAPNS1	ENSMLUP00000014627	ENSMLUP00000017097	Calpastatin.	Calpain small subunit 1.	0.986
CAST	GCA	ENSMLUP00000014627	ENSMLUP00000008685	Calpastatin.	Grancalcin.	0.861
CAST	PEF1	ENSMLUP00000014627	ENSMLUP00000008371	Calpastatin.	Penta-EF-hand domain containing 1.	0.860
CAST	SRI	ENSMLUP00000014627	ENSMLUP00000012732	Calpastatin.	Sorcin.	0.865
GCA	CAPN13	ENSMLUP00000008685	ENSMLUP00000007307	Grancalcin.	Calpain 13; Belongs to the peptidase C2 family.	0.692

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009165

Nucleotide biosynthetic process

6 of 182

1.75

2.29

3.91e-06

GO:0009152

Purine ribonucleotide biosynthetic process

5 of 122

1.84

2.21

1.37e-05

GO:0009132

Nucleoside diphosphate metabolic process

4 of 69

1.99

2.17

3.33e-05

GO:0090407

Organophosphate biosynthetic process

7 of 397

1.47

1.89

3.91e-06

GO:0009141

Nucleoside triphosphate metabolic process

4 of 119

1.75

1.72

0.00018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

4 of 29

2.37

2.68

7.11e-06

GO:0019205

Nucleobase-containing compound kinase activity

4 of 40

2.23

2.51

1.17e-05

GO:0004550

Nucleoside diphosphate kinase activity

3 of 15

2.53

2.13

0.00011

GO:0004017

Adenylate kinase activity

2 of 10

2.53

1.02

0.0138

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35194983

(2022) Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation.

7 of 37

2.5

6.06

5.93e-13

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9802

Purine metabolism, and Interconversion of nucleotide di- and triphosphates

8 of 90

2.18

5.5

2.87e-13

CL:9804

Purine metabolism

7 of 76

2.19

5.05

6.68e-12

CL:9865

Mixed, incl. Purine ribonucleoside monophosphate biosynthetic process, and Uridine-diphosphatase activity

4 of 26

2.42

3.14

8.94e-07

CL:9919

Adenylate kinase activity, and dATP metabolic process

3 of 10

2.71

2.58

1.74e-05

CL:9923

Adenylate kinase activity

2 of 5

2.83

1.46

0.0022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

acs00230

Purine metabolism

8 of 117

2.06

5.32

8.91e-14

acs00240

Pyrimidine metabolism

3 of 52

1.99

1.82

0.00022

acs00730

Thiamine metabolism

2 of 13

2.42

1.54

0.0014

acs01100

Metabolic pathways

8 of 1303

1.02

1.1

6.73e-06

acs00983

Drug metabolism - other enzymes

2 of 51

1.82

0.94

0.0143

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

4 of 34

2.3

2.63

7.91e-06

MAP-15869

Metabolism of nucleotides

5 of 122

1.84

2.29

7.91e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 5

3.01

2.37

4.96e-05

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 6

2.93

2.36

4.96e-05

IPR001564

Nucleoside diphosphate kinase

2 of 4

2.93

1.13

0.0092

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 6

2.93

2.75

9.68e-06

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