STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFIH1Interferon induced with helicase C domain 1. (1022 aa)    
Predicted Functional Partners:
MAVS
Mitochondrial antiviral signaling protein.
    
 0.997
OASL
2'-5'-oligoadenylate synthetase like.
   
 0.978
DHX58
DExH-box helicase 58.
   
0.977
DDX58
DExD/H-box helicase 58.
   
 
0.966
USP18
USP domain-containing protein; Belongs to the peptidase C19 family.
   
 
 0.962
IFI44
Interferon induced protein 44.
   
  
 0.958
STAT1
Signal transducer and activator of transcription.
   
 0.955
RNF125
Ring finger protein 125.
    
 0.946
PARP9
Poly(ADP-ribose) polymerase family member 9.
   
 
 0.926
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
   
 0.924
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.