ICOS protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CD40LG	ENSMLUP00000011740	ENSMLUP00000007096	BCL6 transcription repressor.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.793
BCL6	CTLA4	ENSMLUP00000011740	ENSMLUP00000008749	BCL6 transcription repressor.	Cytotoxic T-lymphocyte associated protein 4.	0.683
BCL6	ICOS	ENSMLUP00000011740	ENSMLUP00000008760	BCL6 transcription repressor.	Inducible T cell costimulator.	0.908
BCL6	LOC102419600	ENSMLUP00000011740	ENSMLUP00000008822	BCL6 transcription repressor.	Uncharacterized protein.	0.585
CD40LG	BCL6	ENSMLUP00000007096	ENSMLUP00000011740	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	BCL6 transcription repressor.	0.793
CD40LG	CTLA4	ENSMLUP00000007096	ENSMLUP00000008749	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Cytotoxic T-lymphocyte associated protein 4.	0.811
CD40LG	ICOS	ENSMLUP00000007096	ENSMLUP00000008760	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Inducible T cell costimulator.	0.991
CD40LG	LOC102419600	ENSMLUP00000007096	ENSMLUP00000008822	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Uncharacterized protein.	0.557
CTLA4	BCL6	ENSMLUP00000008749	ENSMLUP00000011740	Cytotoxic T-lymphocyte associated protein 4.	BCL6 transcription repressor.	0.683
CTLA4	CD40LG	ENSMLUP00000008749	ENSMLUP00000007096	Cytotoxic T-lymphocyte associated protein 4.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.811
CTLA4	G1NVZ4_MYOLU	ENSMLUP00000008749	ENSMLUP00000001469	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.815
CTLA4	ICOS	ENSMLUP00000008749	ENSMLUP00000008760	Cytotoxic T-lymphocyte associated protein 4.	Inducible T cell costimulator.	0.930
CTLA4	LOC102419600	ENSMLUP00000008749	ENSMLUP00000008822	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.956
CTLA4	PIK3CA	ENSMLUP00000008749	ENSMLUP00000008418	Cytotoxic T-lymphocyte associated protein 4.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family.	0.793
CTLA4	PIK3CB	ENSMLUP00000008749	ENSMLUP00000000118	Cytotoxic T-lymphocyte associated protein 4.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.785
CTLA4	PIK3CD	ENSMLUP00000008749	ENSMLUP00000007354	Cytotoxic T-lymphocyte associated protein 4.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.785
CTLA4	PIK3R1	ENSMLUP00000008749	ENSMLUP00000014043	Cytotoxic T-lymphocyte associated protein 4.	Phosphoinositide-3-kinase regulatory subunit 1.	0.955
CTLA4	PIK3R2	ENSMLUP00000008749	ENSMLUP00000003615	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.815
G1NVZ4_MYOLU	CTLA4	ENSMLUP00000001469	ENSMLUP00000008749	Uncharacterized protein.	Cytotoxic T-lymphocyte associated protein 4.	0.815
G1NVZ4_MYOLU	ICOS	ENSMLUP00000001469	ENSMLUP00000008760	Uncharacterized protein.	Inducible T cell costimulator.	0.984