PAX8 protein (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PAX8

Paired box 8. (458 aa)

Predicted Functional Partners:

PPARG

0.931

PRKACB

0.901

PRKACA

0.901

RXRB

0.880

RXRG

0.880

PRKCB

0.875

PRKCG

0.875

RXRA

0.873

PRKCA

0.859

G1QFY8_MYOLU

0.859

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G1QFY8_MYOLU	PAX8	ENSMLUP00000022621	ENSMLUP00000010886	Uncharacterized protein.	Paired box 8.	0.859
G1QFY8_MYOLU	PRKCG	ENSMLUP00000022621	ENSMLUP00000014127	Uncharacterized protein.	Protein kinase C gamma; Belongs to the protein kinase superfamily.	0.941
PAX8	G1QFY8_MYOLU	ENSMLUP00000010886	ENSMLUP00000022621	Paired box 8.	Uncharacterized protein.	0.859
PAX8	PPARG	ENSMLUP00000010886	ENSMLUP00000016088	Paired box 8.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.931
PAX8	PRKACA	ENSMLUP00000010886	ENSMLUP00000007530	Paired box 8.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.901
PAX8	PRKACB	ENSMLUP00000010886	ENSMLUP00000003022	Paired box 8.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.901
PAX8	PRKCA	ENSMLUP00000010886	ENSMLUP00000001461	Paired box 8.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.859
PAX8	PRKCB	ENSMLUP00000010886	ENSMLUP00000006287	Paired box 8.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.875
PAX8	PRKCG	ENSMLUP00000010886	ENSMLUP00000014127	Paired box 8.	Protein kinase C gamma; Belongs to the protein kinase superfamily.	0.875
PAX8	RXRA	ENSMLUP00000010886	ENSMLUP00000009549	Paired box 8.	Retinoid X receptor alpha.	0.873
PAX8	RXRB	ENSMLUP00000010886	ENSMLUP00000012885	Paired box 8.	Retinoid X receptor beta.	0.880
PAX8	RXRG	ENSMLUP00000010886	ENSMLUP00000022679	Paired box 8.	Retinoid X receptor gamma.	0.880
PPARG	PAX8	ENSMLUP00000016088	ENSMLUP00000010886	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Paired box 8.	0.931
PPARG	PRKACA	ENSMLUP00000016088	ENSMLUP00000007530	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.774
PPARG	PRKACB	ENSMLUP00000016088	ENSMLUP00000003022	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.774
PPARG	RXRA	ENSMLUP00000016088	ENSMLUP00000009549	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Retinoid X receptor alpha.	0.999
PPARG	RXRB	ENSMLUP00000016088	ENSMLUP00000012885	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Retinoid X receptor beta.	0.975
PPARG	RXRG	ENSMLUP00000016088	ENSMLUP00000022679	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Retinoid X receptor gamma.	0.990
PRKACA	PAX8	ENSMLUP00000007530	ENSMLUP00000010886	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Paired box 8.	0.901
PRKACA	PPARG	ENSMLUP00000007530	ENSMLUP00000016088	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.774