STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)    
Predicted Functional Partners:
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
    
 0.999
TGFBR2
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
    
 0.999
LTBP1
Latent transforming growth factor beta binding protein 1.
   
 0.996
LTBP3
Latent transforming growth factor beta binding protein 3.
   
 0.991
G1P4J7_MYOLU
Uncharacterized protein.
   
 0.990
ITGAV
Integrin subunit alpha V; Belongs to the integrin alpha chain family.
   
 0.990
ITGB6
Integrin beta; Belongs to the integrin beta chain family.
   
 0.985
DCN
Decorin; May affect the rate of fibrils formation.
    
 0.984
ITGB8
Integrin beta; Belongs to the integrin beta chain family.
   
 0.977
PCSK4
Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family.
    
 0.971
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.