STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (604 aa)    
Predicted Functional Partners:
PLK1
Serine/threonine-protein kinase PLK.
   
 
  0.980
CDC20
Cell division cycle 20.
   
 
  0.969
CEP55
Centrosomal protein 55.
   
  
 0.825
G1PAX2_MYOLU
BUB1 N-terminal domain-containing protein.
   
 
 0.822
CKAP2L
Cytoskeleton associated protein 2 like.
   
    0.790
PLK4
Polo like kinase 4.
   
 
  0.709
NDC80
NDC80 kinetochore complex component.
   
 
 0.683
FZR1
Fizzy and cell division cycle 20 related 1.
   
 
  0.677
ESPL1
Extra spindle pole bodies like 1, separase.
   
 
  0.633
INTU
Inturned planar cell polarity protein.
   
 
  0.626
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.