STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (540 aa)    
Predicted Functional Partners:
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
   
 0.980
FOSB
FosB proto-oncogene, AP-1 transcription factor subunit.
   
 0.963
G1Q234_MYOLU
BZIP domain-containing protein; Belongs to the bZIP family.
   
 0.962
EP300
E1A binding protein p300.
    
 0.926
NAB1
NGFI-A binding protein 1.
    
 0.919
MAPK3
Mitogen-activated protein kinase.
   
 0.918
G1P5Y1_MYOLU
Mitogen-activated protein kinase.
   
 0.907
NAB2
NGFI-A binding protein 2.
   
 0.907
G1QER2_MYOLU
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.907
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
   
 0.881
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.