STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (117 aa)    
Predicted Functional Partners:
SCAP
SREBF chaperone.
   
 0.961
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.928
CHAF1B
Chromatin assembly factor 1 subunit B.
    
 
 0.885
AMFR
Autocrine motility factor receptor.
    
 
 0.844
NPC1
NPC intracellular cholesterol transporter 1.
   
 0.811
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
   
 0.811
ORC5
Origin recognition complex subunit 5.
    
   0.789
ORC3
Origin recognition complex subunit 3.
    
   0.789
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.774
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.716
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.