STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRS1Insulin receptor substrate 1. (1231 aa)    
Predicted Functional Partners:
PTPN11
Protein tyrosine phosphatase non-receptor type 11.
    
 0.999
GRB2
Growth factor receptor bound protein 2.
    
 0.992
INSR
Tyrosine-protein kinase receptor.
   
 0.989
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.989
IGF1R
Tyrosine-protein kinase receptor.
   
 0.989
G1NVZ4_MYOLU
Uncharacterized protein.
    
 0.983
JAK2
Tyrosine-protein kinase.
    
 0.980
G1PG23_MYOLU
Receptor protein-tyrosine kinase.
    
 0.971
PIK3CA
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family.
   
 0.966
LYN
Tyrosine-protein kinase.
    
 0.965
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.