node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KLU01488.1 | KLU01490.1 | RISK_006644 | RISK_006646 | Protein containing DUF4112. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.625 |
KLU01488.1 | KLU01491.1 | RISK_006644 | RISK_006647 | Protein containing DUF4112. | Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase. | 0.468 |
KLU01488.1 | tsaD | RISK_006644 | RISK_006645 | Protein containing DUF4112. | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.625 |
KLU01490.1 | KLU01488.1 | RISK_006646 | RISK_006644 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Protein containing DUF4112. | 0.625 |
KLU01490.1 | KLU01491.1 | RISK_006646 | RISK_006647 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase. | 0.568 |
KLU01490.1 | tsaD | RISK_006646 | RISK_006645 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.782 |
KLU01491.1 | KLU01488.1 | RISK_006647 | RISK_006644 | Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase. | Protein containing DUF4112. | 0.468 |
KLU01491.1 | KLU01490.1 | RISK_006647 | RISK_006646 | Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.568 |
KLU01491.1 | tsaD | RISK_006647 | RISK_006645 | Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase. | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.569 |
KLU04029.1 | KLU07337.1 | RISK_003998 | RISK_000415 | TsaE protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA. | TsaB protein, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA. | 0.990 |
KLU04029.1 | metG | RISK_003998 | RISK_004774 | TsaE protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA. | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.473 |
KLU04029.1 | polA | RISK_003998 | RISK_002862 | TsaE protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.538 |
KLU04029.1 | tsaD | RISK_003998 | RISK_006645 | TsaE protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA. | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.946 |
KLU07337.1 | KLU04029.1 | RISK_000415 | RISK_003998 | TsaB protein, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA. | TsaE protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA. | 0.990 |
KLU07337.1 | tsaD | RISK_000415 | RISK_006645 | TsaB protein, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA. | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.982 |
KLU07750.1 | metG | RISK_000267 | RISK_004774 | Translation elongation factor G. | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.437 |
KLU07750.1 | pheS | RISK_000267 | RISK_003616 | Translation elongation factor G. | Phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.728 |
KLU07750.1 | tsaD | RISK_000267 | RISK_006645 | Translation elongation factor G. | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.527 |
aroB | tsaD | RISK_003269 | RISK_006645 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | TsaD/Kae1/Qri7 protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.514 |
metG | KLU04029.1 | RISK_004774 | RISK_003998 | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | TsaE protein, required for threonylcarbamoyladenosine t(6)A37 formation in tRNA. | 0.473 |