STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (318 aa)    
Predicted Functional Partners:
Tola_0621
Aspartate kinase; KEGG: aha:AHA_3018 bifunctional aspartokinase I/homeserine dehydrogenase I; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
 0.999
Tola_0623
KEGG: aha:AHA_3016 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.
 
 0.999
Tola_0129
Aspartate kinase; KEGG: aha:AHA_0590 bifunctional aspartate kinase II/homoserine dehydrogenase II; TIGRFAM: aspartate kinase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; aspartate/glutamate/uridylate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
 0.998
Tola_2127
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.890
Tola_1497
PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ppw:PputW619_2128 pyridoxal-5'-phosphate-dependent protein beta subunit.
  
 
 0.881
Tola_0128
KEGG: aha:AHA_0589 O-succinylhomoserine (thiol)-lyase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein.
  
 
 0.847
Tola_0442
KEGG: mmw:Mmwyl1_3280 L-serine dehydratase 1; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.844
metE
5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
   
 
 0.839
Tola_2151
KEGG: asa:ASA_2578 aspartate kinase III; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family.
 
 
 0.838
Tola_2761
KEGG: aha:AHA_0192 serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: serine acetyltransferase domain protein; transferase hexapeptide repeat containing protein.
     
 0.836
Your Current Organism:
Tolumonas auensis
NCBI taxonomy Id: 595494
Other names: T. auensis DSM 9187, Tolumonas auensis DSM 9187, Tolumonas auensis TA 4, Tolumonas auensis str. DSM 9187, Tolumonas auensis strain DSM 9187
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