STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tola_1433KEGG: sbn:Sbal195_0116 hypothetical protein. (225 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.701
Tola_0645
KEGG: sbn:Sbal195_0449 hypothetical protein.
  
    0.519
Tola_2615
PFAM: Sporulation domain protein; KEGG: asa:ASA_1127 hypothetical protein.
  
    0.512
Tola_1149
KEGG: asa:ASA_0611 hypothetical protein.
  
    0.506
Tola_1451
KEGG: asa:ASA_1832 hypothetical protein.
  
     0.485
Tola_1430
TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: asa:ASA_1947 phosphoglycolate phosphatase.
       0.474
ubiG
Ubiquinone biosynthesis O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
       0.474
Tola_2220
KEGG: asa:ASA_1542 hypothetical protein; Belongs to the UPF0319 family.
  
     0.433
Tola_0634
PFAM: protein of unknown function DUF1439; KEGG: asa:ASA_1289 lipoprotein.
  
     0.431
Tola_2708
TIGRFAM: cyd operon protein YbgT; PFAM: membrane bound YbgT family protein; KEGG: aha:AHA_3644 cyd operon protein YbgT.
  
     0.419
Your Current Organism:
Tolumonas auensis
NCBI taxonomy Id: 595494
Other names: T. auensis DSM 9187, Tolumonas auensis DSM 9187, Tolumonas auensis TA 4, Tolumonas auensis str. DSM 9187, Tolumonas auensis strain DSM 9187
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