node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0127 | dcd | Tola_0127 | Tola_1528 | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.559 |
Tola_0418 | Tola_1428 | Tola_0418 | Tola_1428 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | PFAM: ribonucleotide reductase; KEGG: stm:STM2278 ribonucleotide-diphosphate reductase subunit beta. | 0.603 |
Tola_0418 | Tola_1429 | Tola_0418 | Tola_1429 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.440 |
Tola_0418 | Tola_2744 | Tola_0418 | Tola_2744 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: aha:AHA_0819 MazG family protein. | 0.900 |
Tola_0418 | dcd | Tola_0418 | Tola_1528 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.908 |
Tola_0418 | dut | Tola_0418 | Tola_0185 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.926 |
Tola_0418 | ndk | Tola_0418 | Tola_2012 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.916 |
Tola_0418 | pyrG | Tola_0418 | Tola_2743 | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.910 |
Tola_1428 | Tola_0418 | Tola_1428 | Tola_0418 | PFAM: ribonucleotide reductase; KEGG: stm:STM2278 ribonucleotide-diphosphate reductase subunit beta. | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | 0.603 |
Tola_1428 | Tola_1429 | Tola_1428 | Tola_1429 | PFAM: ribonucleotide reductase; KEGG: stm:STM2278 ribonucleotide-diphosphate reductase subunit beta. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
Tola_1428 | dcd | Tola_1428 | Tola_1528 | PFAM: ribonucleotide reductase; KEGG: stm:STM2278 ribonucleotide-diphosphate reductase subunit beta. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.527 |
Tola_1428 | ndk | Tola_1428 | Tola_2012 | PFAM: ribonucleotide reductase; KEGG: stm:STM2278 ribonucleotide-diphosphate reductase subunit beta. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.918 |
Tola_1429 | Tola_0418 | Tola_1429 | Tola_0418 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | 0.440 |
Tola_1429 | Tola_1428 | Tola_1429 | Tola_1428 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | PFAM: ribonucleotide reductase; KEGG: stm:STM2278 ribonucleotide-diphosphate reductase subunit beta. | 0.999 |
Tola_1429 | dcd | Tola_1429 | Tola_1528 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.626 |
Tola_1429 | dut | Tola_1429 | Tola_0185 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.776 |
Tola_1429 | ndk | Tola_1429 | Tola_2012 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.922 |
Tola_1530 | dcd | Tola_1530 | Tola_1528 | Mrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.586 |
Tola_1530 | udk | Tola_1530 | Tola_1529 | Mrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. | KEGG: aha:AHA_2235 uridine kinase; TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase. | 0.633 |
Tola_2744 | Tola_0418 | Tola_2744 | Tola_0418 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: aha:AHA_0819 MazG family protein. | KEGG: ent:Ent638_0437 anaerobic ribonucleoside triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | 0.900 |