| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Tola_2382 | Tola_2383 | Tola_2382 | Tola_2383 | HflC protein; HflC and HflK could regulate a protease. | HflK protein; HflC and HflK could encode or regulate a protease. | 0.984 |
| Tola_2382 | Tola_2388 | Tola_2382 | Tola_2388 | HflC protein; HflC and HflK could regulate a protease. | KEGG: ppr:PBPRA3353 putative N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; Peptidoglycan-binding LysM; SMART: cell wall hydrolase/autolysin; Peptidoglycan-binding LysM. | 0.507 |
| Tola_2382 | ftsH | Tola_2382 | Tola_2252 | HflC protein; HflC and HflK could regulate a protease. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.878 |
| Tola_2382 | hflX | Tola_2382 | Tola_2384 | HflC protein; HflC and HflK could regulate a protease. | GTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.796 |
| Tola_2382 | hfq | Tola_2382 | Tola_2385 | HflC protein; HflC and HflK could regulate a protease. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.558 |
| Tola_2382 | miaA | Tola_2382 | Tola_2386 | HflC protein; HflC and HflK could regulate a protease. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.530 |
| Tola_2382 | nnrD | Tola_2382 | Tola_2390 | HflC protein; HflC and HflK could regulate a protease. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.565 |
| Tola_2382 | nuoC | Tola_2382 | Tola_2642 | HflC protein; HflC and HflK could regulate a protease. | NADH dehydrogenase I, D subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.547 |
| Tola_2382 | purA | Tola_2382 | Tola_2381 | HflC protein; HflC and HflK could regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.567 |
| Tola_2382 | yidC | Tola_2382 | Tola_3167 | HflC protein; HflC and HflK could regulate a protease. | 60 kDa inner membrane insertion protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.482 |
| Tola_2383 | Tola_2382 | Tola_2383 | Tola_2382 | HflK protein; HflC and HflK could encode or regulate a protease. | HflC protein; HflC and HflK could regulate a protease. | 0.984 |
| Tola_2383 | Tola_2388 | Tola_2383 | Tola_2388 | HflK protein; HflC and HflK could encode or regulate a protease. | KEGG: ppr:PBPRA3353 putative N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; Peptidoglycan-binding LysM; SMART: cell wall hydrolase/autolysin; Peptidoglycan-binding LysM. | 0.514 |
| Tola_2383 | ftsH | Tola_2383 | Tola_2252 | HflK protein; HflC and HflK could encode or regulate a protease. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.958 |
| Tola_2383 | hflX | Tola_2383 | Tola_2384 | HflK protein; HflC and HflK could encode or regulate a protease. | GTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.913 |
| Tola_2383 | hfq | Tola_2383 | Tola_2385 | HflK protein; HflC and HflK could encode or regulate a protease. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.597 |
| Tola_2383 | miaA | Tola_2383 | Tola_2386 | HflK protein; HflC and HflK could encode or regulate a protease. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.627 |
| Tola_2383 | nnrD | Tola_2383 | Tola_2390 | HflK protein; HflC and HflK could encode or regulate a protease. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.565 |
| Tola_2383 | nuoC | Tola_2383 | Tola_2642 | HflK protein; HflC and HflK could encode or regulate a protease. | NADH dehydrogenase I, D subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family. | 0.547 |
| Tola_2383 | purA | Tola_2383 | Tola_2381 | HflK protein; HflC and HflK could encode or regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.589 |
| Tola_2383 | yidC | Tola_2383 | Tola_3167 | HflK protein; HflC and HflK could encode or regulate a protease. | 60 kDa inner membrane insertion protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.646 |