STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
birAbiotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (321 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.950
Tola_2899
KEGG: cja:CJA_2723 UreA amidolyase homolog; TIGRFAM: urea carboxylase; urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; Allophanate hydrolase subunit 1; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; SMART: Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1.
 
  
 0.948
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
  
  
 0.936
Tola_1072
PFAM: peptidase M22 glycoprotease; KEGG: aha:AHA_2201 glycoprotease family protein.
 
    0.920
Tola_1847
TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: pap:PSPA7_6224 acetyl-CoA carboxylase.
 
 0.904
Tola_2530
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.904
Tola_0401
TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: pyruvate carboxyltransferase; Conserved carboxylase region; biotin/lipoyl attachment domain-containing protein; KEGG: pmu:PM1422 pyruvate carboxylase subunit B.
 
 
 
 0.821
tadA
CMP/dCMP deaminase zinc-binding; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
 
    0.818
Tola_1848
TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; KEGG: pag:PLES_58301 putative transcarboxylase subunit.
 
 
 
 0.807
Tola_0903
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sbp:Sbal223_1649 exodeoxyribonuclease III.
  
    0.805
Your Current Organism:
Tolumonas auensis
NCBI taxonomy Id: 595494
Other names: T. auensis DSM 9187, Tolumonas auensis DSM 9187, Tolumonas auensis TA 4, Tolumonas auensis str. DSM 9187, Tolumonas auensis strain DSM 9187
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