node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tola_0661 | lipA | Tola_0661 | Tola_2836 | Fe-S cluster assembly protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.499 |
Tola_0661 | nfuA | Tola_0661 | Tola_0510 | Fe-S cluster assembly protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. | IscR-regulated protein YhgI; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.994 |
Tola_2228 | Tola_2574 | Tola_2228 | Tola_2574 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: aha:AHA_3861 dihydrolipoamide dehydrogenase. | 0.996 |
Tola_2228 | lipA | Tola_2228 | Tola_2836 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.662 |
Tola_2228 | lipB | Tola_2228 | Tola_2835 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.639 |
Tola_2574 | Tola_2228 | Tola_2574 | Tola_2228 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: aha:AHA_3861 dihydrolipoamide dehydrogenase. | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.996 |
Tola_2574 | Tola_2575 | Tola_2574 | Tola_2575 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: aha:AHA_3861 dihydrolipoamide dehydrogenase. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.998 |
Tola_2574 | lipA | Tola_2574 | Tola_2836 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: aha:AHA_3861 dihydrolipoamide dehydrogenase. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.624 |
Tola_2574 | lipB | Tola_2574 | Tola_2835 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: aha:AHA_3861 dihydrolipoamide dehydrogenase. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.513 |
Tola_2575 | Tola_2574 | Tola_2575 | Tola_2574 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: aha:AHA_3861 dihydrolipoamide dehydrogenase. | 0.998 |
Tola_2575 | lipA | Tola_2575 | Tola_2836 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.636 |
Tola_2575 | lipB | Tola_2575 | Tola_2835 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.685 |
Tola_2833 | Tola_2834 | Tola_2833 | Tola_2834 | Beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: aha:AHA_3259 penicillin-binding protein; Belongs to the peptidase S11 family. | PFAM: protein of unknown function DUF493; KEGG: aha:AHA_3260 hypothetical protein; Belongs to the UPF0250 family. | 0.635 |
Tola_2833 | lipA | Tola_2833 | Tola_2836 | Beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: aha:AHA_3259 penicillin-binding protein; Belongs to the peptidase S11 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.431 |
Tola_2833 | lipB | Tola_2833 | Tola_2835 | Beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: aha:AHA_3259 penicillin-binding protein; Belongs to the peptidase S11 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.431 |
Tola_2834 | Tola_2833 | Tola_2834 | Tola_2833 | PFAM: protein of unknown function DUF493; KEGG: aha:AHA_3260 hypothetical protein; Belongs to the UPF0250 family. | Beta-lactamase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: aha:AHA_3259 penicillin-binding protein; Belongs to the peptidase S11 family. | 0.635 |
Tola_2834 | Tola_2837 | Tola_2834 | Tola_2837 | PFAM: protein of unknown function DUF493; KEGG: aha:AHA_3260 hypothetical protein; Belongs to the UPF0250 family. | PFAM: protein of unknown function DUF218; KEGG: asa:ASA_3722 SanA protein. | 0.430 |
Tola_2834 | lipA | Tola_2834 | Tola_2836 | PFAM: protein of unknown function DUF493; KEGG: aha:AHA_3260 hypothetical protein; Belongs to the UPF0250 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.670 |
Tola_2834 | lipB | Tola_2834 | Tola_2835 | PFAM: protein of unknown function DUF493; KEGG: aha:AHA_3260 hypothetical protein; Belongs to the UPF0250 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.761 |
Tola_2837 | Tola_2834 | Tola_2837 | Tola_2834 | PFAM: protein of unknown function DUF218; KEGG: asa:ASA_3722 SanA protein. | PFAM: protein of unknown function DUF493; KEGG: aha:AHA_3260 hypothetical protein; Belongs to the UPF0250 family. | 0.430 |