CAOG_005605 protein (Capsaspora owczarzaki) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CAOG_005605

Vacuolar protein sorting 53. (908 aa)

Predicted Functional Partners:

CAOG_002502

0.997

CAOG_001004

0.996

CAOG_004079

0.990

CAOG_008840

0.965

CAOG_001507

0.870

CAOG_007832

0.862

CAOG_005240

0.825

CAOG_001886

0.812

CAOG_002479

0.799

CAOG_001298

0.790

Your Current Organism:

Capsaspora owczarzaki

NCBI taxonomy Id: 595528
Other names: C. owczarzaki ATCC 30864, Capsaspora owczarzaki ATCC 30864

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAOG_001004	CAOG_001298	A0A0D2X0S3	A0A0D2X0Y9	Uncharacterized protein.	Tethering factor SEC34.	0.722
CAOG_001004	CAOG_001507	A0A0D2X0S3	A0A0D2WJF6	Uncharacterized protein.	Ras-like protein Rab-6A.	0.655
CAOG_001004	CAOG_001886	A0A0D2X0S3	A0A0D2U643	Uncharacterized protein.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.779
CAOG_001004	CAOG_002479	A0A0D2X0S3	A0A0D2VME3	Uncharacterized protein.	Uncharacterized protein.	0.784
CAOG_001004	CAOG_002502	A0A0D2X0S3	A0A0D2WMG9	Uncharacterized protein.	Uncharacterized protein.	0.968
CAOG_001004	CAOG_004079	A0A0D2X0S3	A0A0D2VR09	Uncharacterized protein.	Vacuolar protein sorting 52.	0.979
CAOG_001004	CAOG_005240	A0A0D2X0S3	A0A0D2WRQ3	Uncharacterized protein.	Syntaxin-6.	0.903
CAOG_001004	CAOG_005605	A0A0D2X0S3	A0A0D2WTT6	Uncharacterized protein.	Vacuolar protein sorting 53.	0.996
CAOG_001004	CAOG_008840	A0A0D2X0S3	A0A0D2VSX5	Uncharacterized protein.	Uncharacterized protein.	0.965
CAOG_001298	CAOG_001004	A0A0D2X0Y9	A0A0D2X0S3	Tethering factor SEC34.	Uncharacterized protein.	0.722
CAOG_001298	CAOG_001507	A0A0D2X0Y9	A0A0D2WJF6	Tethering factor SEC34.	Ras-like protein Rab-6A.	0.720
CAOG_001298	CAOG_001886	A0A0D2X0Y9	A0A0D2U643	Tethering factor SEC34.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.752
CAOG_001298	CAOG_002479	A0A0D2X0Y9	A0A0D2VME3	Tethering factor SEC34.	Uncharacterized protein.	0.995
CAOG_001298	CAOG_002502	A0A0D2X0Y9	A0A0D2WMG9	Tethering factor SEC34.	Uncharacterized protein.	0.784
CAOG_001298	CAOG_004079	A0A0D2X0Y9	A0A0D2VR09	Tethering factor SEC34.	Vacuolar protein sorting 52.	0.804
CAOG_001298	CAOG_005240	A0A0D2X0Y9	A0A0D2WRQ3	Tethering factor SEC34.	Syntaxin-6.	0.645
CAOG_001298	CAOG_005605	A0A0D2X0Y9	A0A0D2WTT6	Tethering factor SEC34.	Vacuolar protein sorting 53.	0.790
CAOG_001507	CAOG_001004	A0A0D2WJF6	A0A0D2X0S3	Ras-like protein Rab-6A.	Uncharacterized protein.	0.655
CAOG_001507	CAOG_001298	A0A0D2WJF6	A0A0D2X0Y9	Ras-like protein Rab-6A.	Tethering factor SEC34.	0.720
CAOG_001507	CAOG_001886	A0A0D2WJF6	A0A0D2U643	Ras-like protein Rab-6A.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.794

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

3.6e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030834

Regulation of actin filament depolymerization

5 of 13

2.28

3.25

3.27e-07

GO:0030837

Negative regulation of actin filament polymerization

5 of 14

2.24

3.23

3.27e-07

GO:0051016

Barbed-end actin filament capping

4 of 10

2.29

2.93

1.74e-06

GO:0007010

Cytoskeleton organization

7 of 140

1.39

1.89

6.31e-07

GO:0030036

Actin cytoskeleton organization

5 of 76

1.51

1.72

3.18e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051015

Actin filament binding

6 of 24

2.09

3.68

1.01e-08

GO:0044877

Protein-containing complex binding

7 of 145

1.38

1.8

1.57e-06

GO:0005200

Structural constituent of cytoskeleton

3 of 10

2.17

1.73

0.00047

GO:0005515

Protein binding

7 of 607

0.75

0.51

0.0112

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

10 of 59

1.92

5.33

4.84e-16

GO:0005869

Dynactin complex

4 of 4

2.69

3.62

1.67e-07

GO:0005856

Cytoskeleton

11 of 171

1.5

3.16

1.77e-14

GO:0008290

F-actin capping protein complex

3 of 3

2.69

2.73

8.80e-06

GO:0030479

Actin cortical patch

5 of 37

1.82

2.55

1.27e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30323040

(2019) A Novel Actin Binding Drug with In Vivo Efficacy.

2 of 2

2.69

1.14

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1450

Microtubule associated complex, and F-actin capping protein complex

7 of 11

2.5

6.12

4.14e-13

CL:1452

Dynactin complex, and Actin capping

5 of 5

2.69

4.72

1.07e-09

CL:2177

Actin cortical patch, and Actin polymerization or depolymerization

3 of 28

1.72

1.16

0.0042

CL:2198

Actin filament depolymerization, and Calponin homology domain

2 of 6

2.21

1.0

0.0141

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-109582

Hemostasis

5 of 80

1.49

1.42

0.00032

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 32

1.66

0.87

0.0174

MAP-6807878

COPI-mediated anterograde transport

3 of 43

1.54

0.76

0.0266

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015629

Actin cytoskeleton

8 of 50

1.9

4.24

7.60e-12

GOCC:0005856

Cytoskeleton

10 of 134

1.56

3.22

1.25e-12

GOCC:0005875

Microtubule associated complex

4 of 13

2.18

2.6

6.51e-06

GOCC:0008290

F-actin capping protein complex

3 of 3

2.69

2.56

1.87e-05

GOCC:0005869

Dynactin complex

3 of 3

2.69

2.56

1.87e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 12

2.09

1.65

0.00061

KW-0117

Actin capping

2 of 2

2.69

1.43

0.0025

KW-0206

Cytoskeleton

2 of 14

1.85

0.78

0.0325

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042276

F-actin-capping protein subunit alpha/beta, domain 2

2 of 2

2.69

0.72

0.0496

IPR037282

F-actin-capping protein subunit alpha/beta

2 of 2

2.69

0.72

0.0496

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