STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (693 aa)    
Predicted Functional Partners:
leuS
KEGG: dma:DMR_04560 leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.939
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.931
EFL53073.1
KEGG: dma:DMR_20070 pyruvate-flavodoxin oxidoreductase; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin iron-sulfur binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
   
   0.921
EFL52482.1
PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: dma:DMR_00320 rRNA (cytosine-C(5)-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.897
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
   
 0.873
EFL50603.1
PFAM: UvrD/REP helicase; PHP domain protein; KEGG: dma:DMR_39500 UvrD/REP helicase family protein.
  
  
 0.834
EFL51161.1
PFAM: UvrD/REP helicase; KEGG: dma:DMR_07030 ATP-dependent DNA helicase.
  
  
 0.815
uvrC
Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
  
 0.811
EFL51359.1
PFAM: glycosyl transferase family 2; KEGG: dma:DMR_25650 hypothetical protein.
 
    0.810
EFL51361.1
PFAM: TrkA-N domain protein; Ion transport 2 domain protein; TrkA-C domain protein; KEGG: dma:DMR_23650 potassium channel protein.
     
 0.797
Your Current Organism:
Desulfovibrio fructosivorans
NCBI taxonomy Id: 596151
Other names: D. fructosivorans JJ, Desulfovibrio fructosivorans ATCC 49200, Desulfovibrio fructosivorans DSM 3604, Desulfovibrio fructosivorans JJ, Desulfovibrio fructosivorans str. JJ, Desulfovibrio fructosivorans strain JJ, Desulfovibrio fructosovorans JJ
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