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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas9CRISPR-associated protein, Csn1 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this [...] (1029 aa)    
Predicted Functional Partners:
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.971
AEB82634.1
KEGG: vei:Veis_1232 CRISPR-associated Cas2 family protein; TIGRFAM: CRISPR associated protein Cas2; PFAM: Virulence-associated protein D / CRISPR associated protein Cas2.
 
   
 0.951
AEB85644.1
PFAM: Protein of unknown function DUF1814; KEGG: dia:Dtpsy_2171 hypothetical protein.
  
     0.630
AEB85645.1
KEGG: vei:Veis_2691 hypothetical protein.
  
     0.594
rnc
Ribonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
      
 0.577
ruvC
Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
      
 0.577
AEB86698.1
KEGG: avn:Avin_32400 hypothetical protein.
  
     0.551
AEB84889.1
PFAM: Biotin/lipoate A/B protein ligase; KEGG: azo:azo3871 putative lipoate protein ligase.
  
     0.505
AEB84896.1
PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component; KEGG: dia:Dtpsy_1743 tripartite ATP-independent periplasmic transporter DctQ component.
  
     0.495
AEB86965.1
PFAM: Oxidoreductase FAD/NAD(P)-binding; Flavodoxin/nitric oxide synthase; PepSY-associated TM helix; Oxidoreductase, FAD-binding domain; KEGG: ajs:Ajs_4088 oxidoreductase FAD/NAD(P)-binding subunit.
  
    0.481
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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