STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB83015.1TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; KEGG: dia:Dtpsy_0545 histidinol-phosphate phosphatase family protein. (191 aa)    
Predicted Functional Partners:
AEB82864.1
PFAM: Sugar isomerase (SIS); KEGG: dia:Dtpsy_0407 phosphoheptose isomerase.
 
  
 0.973
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.793
AEB85388.1
KEGG: dia:Dtpsy_2251 DNA ligase; PFAM: DNA ligase, ATP-dependent, central.
   
 0.775
hisA
TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; KEGG: ajs:Ajs_0765 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis.
  
  
 0.756
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.741
glyS
TIGRFAM: Glycyl-tRNA synthetase, class IIc, beta subunit; HAMAP: Glycyl-tRNA synthetase, class IIc, beta subunit; KEGG: ajs:Ajs_0528 glycine--tRNA ligase.
       0.739
AEB83016.1
KEGG: ajs:Ajs_0530 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase.
 
  
 0.717
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
  
  
 0.712
glyQ
TIGRFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; KEGG: dac:Daci_1288 glycyl-tRNA synthetase subunit alpha; PFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit.
       0.709
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.692
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.