STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (476 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.973
AEB82546.1
KEGG: ajs:Ajs_0083 methionine synthase (B12-dependent); PFAM: Homocysteine S-methyltransferase.
  
 
 0.944
AEB82631.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.940
AEB85210.1
Cystathionine beta-lyase; KEGG: dia:Dtpsy_1601 Cys/Met metabolism pyridoxal-phosphate-dependent protein; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
  
 0.928
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 0.928
AEB86797.1
TIGRFAM: MTA/SAH nucleosidase; KEGG: dia:Dtpsy_3298 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; PFAM: Nucleoside phosphorylase domain.
    
 0.916
AEB84496.1
TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: ajs:Ajs_1656 O-acetylhomoserine aminocarboxypropyltransferase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
     
 0.913
AEB85271.1
TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: dia:Dtpsy_1588 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
     
 0.913
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.895
AEB85831.1
PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; KEGG: hch:HCH_06702 cysteine synthase.
  
 0.854
Your Current Organism:
Alicycliphilus denitrificans
NCBI taxonomy Id: 596154
Other names: A. denitrificans K601, Alicycliphilus denitrificans DSM 14773, Alicycliphilus denitrificans K601, Alicycliphilus denitrificans str. K601, Alicycliphilus denitrificans strain K601, Pseudomonas sp. K601, beta proteobacterium K601
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